{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:06:40Z","timestamp":1783595200089,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T00:00:00Z","timestamp":1359504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical features of pediatric psoriasis warrant further attention. A national study was conducted to determine the prevalence of scalp and nail involvement and a history of guttate psoriasis at onset according to age, sex, and disease severity. One hundred eighty\u2010one children ages 5 to 17\u00a0years with plaque psoriasis were enrolled in a multicenter, cross\u2010sectional study. Subjects and guardians were asked about a history of scalp and nail involvement and whether the initial presentation was guttate. Peak psoriasis severity was assessed and defined historically as mild psoriasis (<jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>) or severe psoriasis (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>) according to <jats:styled-content style=\"fixed-case\">the P<\/jats:styled-content>hysician's <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lobal <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment and <jats:styled-content style=\"fixed-case\">b<\/jats:styled-content>ody <jats:styled-content style=\"fixed-case\">s<\/jats:styled-content>urface <jats:styled-content style=\"fixed-case\">a<\/jats:styled-content>rea measures. One hundred forty\u2010three (79.0%) subjects reported a history of scalp involvement, and 71 (39.2%) described a history of nail involvement. Boys were less likely than girls to report a history of scalp involvement (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>]\u00a0=\u00a00.40, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]\u00a0=\u00a00.19\u20130.84) but more likely to have had nail involvement (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.01, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.62\u20135.60). Scalp and nail involvement was not related to psoriasis severity. In contrast, subjects with <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> (35.9%) more often reported a history of guttate lesions than did those with <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> (21.8%) (p\u00a0=\u00a0.02). Antecedent streptococcal infection was more common in children with guttate than those with plaque psoriasis at onset (p\u00a0=\u00a0.02) but did not correlate with severity. Sex\u2010related differences in scalp and nail involvement suggest koebnerization. Preceding streptococcal infection predicts guttate morphology but not severity, and initial guttate morphology is associated with eventual greater severity of disease. More aggressive monitoring and management should be considered for guttate psoriasis, given its later association with more severe disease.<\/jats:p>","DOI":"10.1111\/pde.12072","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T10:22:47Z","timestamp":1359541367000},"page":"424-428","source":"Crossref","is-referenced-by-count":96,"title":["Clinical Manifestations of Pediatric Psoriasis: Results of a Multicenter Study in the United States"],"prefix":"10.1111","volume":"30","author":[{"given":"Katherine","family":"Mercy","sequence":"first","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Kwasny","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Cordoro","sequence":"additional","affiliation":[{"name":"University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Menter","sequence":"additional","affiliation":[{"name":"Baylor Research Institute Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wynnis L.","family":"Tom","sequence":"additional","affiliation":[{"name":"University of California at San Diego San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Korman","sequence":"additional","affiliation":[{"name":"University Hospitals Case Medical Center Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Belazarian","sequence":"additional","affiliation":[{"name":"University of Massachusetts Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April W.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"University of California Davis Health System Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moise L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Dell Children's Medical Center Austin Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Paller","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago 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