{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:35:43Z","timestamp":1781303743264,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonatal lupus erythematosus (<jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content>) is a rare acquired autoimmune disease caused by transplacental transfer of maternal immunoglobulin <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> antibodies to the fetus. <jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content> has well\u2010recognized cutaneous features and may also manifest in other organs. The majority of cases are associated with Ro\/<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> and La\/<jats:styled-content style=\"fixed-case\">SSB<\/jats:styled-content> antibodies. Neonatal lupus due to antiribonucleoprotein (<jats:styled-content style=\"fixed-case\">RNP<\/jats:styled-content>) antibodies has rarely been reported. On rare occasions <jats:styled-content style=\"fixed-case\">RNP<\/jats:styled-content> has been found in association with other antibodies. We report a case of <jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content> occurring solely due to <jats:styled-content style=\"fixed-case\">RNP<\/jats:styled-content> antibodies presenting as varicelliform lesions at birth. We recorded the features in our case and 14 additional cases identified in the literature. It is important to recognize that maternal transfer of <jats:styled-content style=\"fixed-case\">RNP<\/jats:styled-content> antibodies may produce the classic cutaneous features of neonatal lupus. The limited case reports of this condition suggest that manifestations are limited to the skin; specifically, there are no reports of cardiac involvement. The long\u2010term outcome remains unknown. <jats:styled-content style=\"fixed-case\">RNP<\/jats:styled-content>\u2010positive, Ro\/La\u2010negative <jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content> seems to represent a different clinical subset of <jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content>. The recognition of <jats:styled-content style=\"fixed-case\">RNP<\/jats:styled-content> antibody <jats:styled-content style=\"fixed-case\">NLE<\/jats:styled-content> as a benign condition limited to the skin is helpful in planning antenatal care for subsequent pregnancies.<\/jats:p>","DOI":"10.1111\/pde.12088","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T07:40:38Z","timestamp":1361518838000},"page":"416-423","source":"Crossref","is-referenced-by-count":34,"title":["Neonatal Lupus Syndrome Associated with Ribonucleoprotein Antibodies"],"prefix":"10.1111","volume":"30","author":[{"given":"Kara","family":"Heelan","sequence":"first","affiliation":[{"name":"Department of Dermatology Our Lady of Lourdes Hospital Drogheda Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Our Lady's Children's Hospital Crumlin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinead M.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Dermatology Our Lady of Lourdes Hospital Drogheda Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198704303161807"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb08705.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1001\/archderm.1992.01680210068009","article-title":"U1RNP antibody\u2010positive neonatal lupus. 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