{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:29:56Z","timestamp":1769635796213,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:00:00Z","timestamp":1368662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A petrolatum and zinc oxide\u2013based ointment containing 0.25% miconazole nitrate is reported to be effective and well tolerated in the treatment of diaper dermatitis complicated by cutaneous candidiasis (DDCC). This prospective, multicenter, open\u2010label, long\u2010term, phase IV study investigated the potential resistance of <jats:italic>Candida<\/jats:italic> spp. to repeated topical use of 0.25% miconazole nitrate in infants age 15\u00a0months and younger with moderate to severe DDCC. For initial and recurring episodes of DDCC over the 2\u2010year study period, subjects were treated with a 7\u2010day course of 0.25% miconazole nitrate ointment (active components: miconazole nitrate 0.25%, zinc oxide 15%, and white petrolatum 81.35%) with a 7\u2010day follow\u2010up. Clinical and mycologic evaluations were conducted before treatment (day 0) and 7\u00a0days after treatment (day 14). Potential resistance to miconazole was defined using an arbitrary breakpoint of minimum inhibitory concentration of 2\u00a0\u03bcg\/mL. There was no evidence of resistance to miconazole in <jats:italic>Candida<\/jats:italic> spp. after single or repeated treatment courses of 0.25% miconazole nitrate ointment. For the initial episode of DDCC, 83 of 168 subjects (49.4%) achieved a clinical cure, 77 (45.8%) achieved a mycologic cure, and 49 (29.2%) achieved an overall cure (clinical and mycologic). The overall cure rate for recurrent episodes of DDCC was similar to or numerically greater than rates observed for the initial episode. Treatment of DDCC with 0.25% miconazole nitrate ointment was effective and generally well tolerated. No evidence of the development of resistance to miconazole in <jats:italic>Candida<\/jats:italic> spp. was observed.<\/jats:p>","DOI":"10.1111\/pde.12107","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T10:42:51Z","timestamp":1368700971000},"page":"717-724","source":"Crossref","is-referenced-by-count":19,"title":["A Prospective Two\u2010Year Assessment of Miconazole Resistance in <i>Candida<\/i> Spp. with Repeated Treatment with 0.25% Miconazole Nitrate Ointment in Neonates and Infants with Moderate to Severe Diaper Dermatitis Complicated by Cutaneous Candidiasis"],"prefix":"10.1111","volume":"30","author":[{"given":"Daisy","family":"Blanco","sequence":"first","affiliation":[{"name":"Institute of Dermatology Santo Domingo Dominican Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"van Rossem","sequence":"additional","affiliation":[{"name":"Stiefel, a GSK company Wavre Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30841-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.018002149.x"},{"key":"e_1_2_7_4_1","first-page":"113","article-title":"Topical miconazole nitrate ointment in the treatment of diaper dermatitis complicated by candidiasis","volume":"77","author":"Spraker MK","year":"2006","journal-title":"Cutis"},{"key":"e_1_2_7_5_1","first-page":"522","article-title":"Absorption and efficacy of miconazole nitrate 0.25% ointment in infants with diaper dermatitis","volume":"6","author":"Eichenfield LF","year":"2007","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02002901"},{"key":"e_1_2_7_7_1","volume-title":"Study of the efficacy and the absorption of miconazole nitrate in infants with diaper dermatitis, alone or associated with systemic pathology","author":"Herrera JC","year":"1989"},{"key":"e_1_2_7_8_1","unstructured":"Fallon FriedlanderS EichenfieldLF LeydenJet\u00a0al.Diaper dermatitis: appropriate evaluation and optimal management strategies. 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