{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:38:45Z","timestamp":1781174325023,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Staphylococcal scalded skin syndrome (<jats:styled-content style=\"fixed-case\">SSSS<\/jats:styled-content>) is a rare disorder in children. Complications may occur without timely treatment. Mortality in children with <jats:styled-content style=\"fixed-case\">SSSS<\/jats:styled-content> is approximately 4%. Other than a limited number of case reports, data on <jats:styled-content style=\"fixed-case\">SSSS<\/jats:styled-content> in neonates are limited. The objective of the current study was to investigate <jats:styled-content style=\"fixed-case\">SSSS<\/jats:styled-content> in neonates. A retrospective review of neonates with a diagnosis of <jats:styled-content style=\"fixed-case\">SSSS<\/jats:styled-content> from January 2004 to January 2012 was performed. Population distribution, historical features, physical examination findings including laboratory tests, antibiotic therapies, and outcomes were evaluated. Thirty\u2010nine cases were included, 31 (79.5%) in the last 4\u00a0years. The mean patient age was 17.4\u00a0\u00b1\u00a07.7\u00a0days. Boys (25 cases) were more commonly affected, and occurrence during summer and autumn months was more frequent. The face was the most common body part affected and the area most commonly initially affected. Fever, high white blood cell count, and high C\u2010reactive protein levels were uncommon. Pneumonia was the most frequent complication (74.4%). The positive rate of <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>taphylococcus aureus<\/jats:italic> isolation was low (23.5%). Drug susceptibility tests showed that amoxicillin with clavulanic acid and cephalosporins were effective in practice. The median length of hospitalization was 9.0\u00a0days. All of the 39 neonates were cured without scarring. This study established basic epidemiologic characteristics of a group of neonates diagnosed with <jats:styled-content style=\"fixed-case\">SSSS<\/jats:styled-content>. In the presence of a clinical suspicion of <jats:styled-content style=\"fixed-case\">SSSS<\/jats:styled-content>, even with apparently normal laboratory tests, immediate treatment with cephalosporins, \u03b2\u2010lactamase\u2010resistant semisynthetic penicillin, or both is advocated.<\/jats:p>","DOI":"10.1111\/pde.12114","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T09:16:58Z","timestamp":1365153418000},"page":"43-47","source":"Crossref","is-referenced-by-count":43,"title":["Staphylococcal Scalded Skin Syndrome in Neonates: An 8\u2010Year Retrospective Study in a Single Institution"],"prefix":"10.1111","volume":"31","author":[{"given":"Ming Y.","family":"Li","sequence":"first","affiliation":[{"name":"Children's Hospital of Chongqing Medical University, Chongqing Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hua","sequence":"additional","affiliation":[{"name":"Children's Hospital of Chongqing Medical University, Chongqing Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang H.","family":"Wei","sequence":"additional","affiliation":[{"name":"Children's Hospital of Chongqing Medical University, Chongqing Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Children's Hospital of Chongqing Medical University, Chongqing Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304030-00003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-009-0212-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23642.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.08.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/498901"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2.4.575"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(99)00094-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.07.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000060826.85530.fb"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.02.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06721.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215766"},{"key":"e_1_2_7_14_1","first-page":"59","article-title":"The 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