{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:56:36Z","timestamp":1785783396722,"version":"3.56.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We recently saw the case of an 8\u2010year\u2010old boy with histologic findings of spiradenocarcinoma. Malignant adnexal tumors in children are exceedingly rare, and cases of spiradenocarcinoma in children are absent in the literature. We report the case of an 8\u2010year\u2010old boy with metastatic spiradenocarcinoma. A biopsy 2\u00a0years before his presentation at our institution was interpreted as a benign lesion, but when the lesion regrew, a repeat biopsy was performed that demonstrated ominous findings, prompting a reexcision. This reexcision demonstrated an area with significant necrosis, many mitoses, and cellular pleomorphism apparently arising out of a sharply demarcated, adjacent, lower\u2010grade area. The histologic features of this patient's biopsies were those of spiradenocarcinoma, potentially arising out of a preexisting spiradenoma, a finding that has not been documented previously in this age group. Staging studies demonstrated multiple bilateral pulmonary nodules, which were confirmed using thoracoscopic biopsy to be metastatic disease. His chemotherapy regimen has included several cycles of cisplatin and 5\u2010flourouracil, with ongoing disease progression of pulmonary disease. It has been 16\u00a0months since he presented to our institution (&gt;3\u00a0years since the appearance of his initial lesion). Imaging studies demonstrate a slowly increasing size and number of pulmonary lesions. The long\u2010term prognosis is guarded.<\/jats:p>","DOI":"10.1111\/pde.12136","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T08:12:38Z","timestamp":1366013558000},"page":"122-127","source":"Crossref","is-referenced-by-count":13,"title":["Metastatic Spiradenocarcinoma Occurring in an 8\u2010Year\u2010Old Boy"],"prefix":"10.1111","volume":"32","author":[{"given":"Jayson R.","family":"Miedema","sequence":"first","affiliation":[{"name":"Department of Pathology University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Burgon","sequence":"additional","affiliation":[{"name":"School of Medicine University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Burkhart","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of North Carolina Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyn","family":"Stitzenberg","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill North Carolina"},{"name":"Department of Surgery University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hipps","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill North Carolina"},{"name":"Department of Pediatric Hematology\/Oncology University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zedek","sequence":"additional","affiliation":[{"name":"Department of Pathology University of North Carolina Chapel Hill North Carolina"},{"name":"Department of Dermatology University of North Carolina Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200004000-00002"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.107471"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/2002-126-0591-MES"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1985.01660110093023"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1987.tb00122.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198704000-00002"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1983.tb00333.x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01609.x"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.229"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.04.015"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318255dd37"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12136","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:52:58Z","timestamp":1696193578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,15]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/pde.12136"],"URL":"https:\/\/doi.org\/10.1111\/pde.12136","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,15]]}}}