{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:22:32Z","timestamp":1773757352215,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T00:00:00Z","timestamp":1367193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of oxybutynin for treating hyperhidrosis in children are still unknown. Therefore the aim of this study was to investigate the effects of oxybutynin on improving symptoms of hyperhidrosis and quality of life (<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) in children with palmar hyperhidrosis (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>). Forty\u2010five children ages 7\u201314\u00a0years with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> were evaluated 6\u00a0weeks after protocol treatment with oxybutynin. <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> was evaluated before and after treatment using a validated clinical questionnaire. More than 85% of the children with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> treated with oxybutynin experienced moderate or greater improvement in the level of sweating and 80% experienced improvement in <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>. Children who initially presented with very poor <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> were those who benefited most from oxybutynin therapy. Side effects occurred in 25 children (55.5%) and were mainly dry mouth. Only one patient had neurologic symptoms, which was reported as drowsiness. Oxybutynin is an effective treatment option for children with <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> because it improves clinical symptoms and <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>. Further studies are required to determine the long\u2010term outcomes of treatment with oxybutynin.<\/jats:p>","DOI":"10.1111\/pde.12142","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T04:09:14Z","timestamp":1367294954000},"page":"48-53","source":"Crossref","is-referenced-by-count":57,"title":["Efficacy and Quality of Life Outcomes of Oxybutynin for Treating Palmar Hyperhidrosis in Children Younger than 14\u00a0Years Old"],"prefix":"10.1111","volume":"31","author":[{"given":"Nelson","family":"Wolosker","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"},{"name":"Department of Vascular Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Schvartsman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital 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