{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:29:43Z","timestamp":1790040583051,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Calcipotriene is a topical vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>3 analogue approved for the treatment of plaque and scalp psoriasis. We report the case of a 2\u2010year\u2010old boy whose atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) flared in response to application of calcipotriene 0.005% cream and solution for a mistaken diagnosis of plaque and scalp psoriasis. We investigated whether the patient's eruption was secondary to an allergic contact dermatitis. In the Stat6<jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content> mouse model of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> we tested whether calcipotriene could induce the otherwise\u2010spontaneous <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like phenotype. Closed patch testing was done on the patient with calcipotriene solution and cream, moisturizing cream, and 51% isopropanol. Stat6<jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content> and wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) mice were treated for 7\u00a0days with calcipotriene solution or vehicle (isopropanol) applied to the right and left upper back skin, respectively, after which mice were followed longitudinally for 10\u00a0weeks. Biopsy specimens from prior treatment sites were then collected for histology and <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> isolation. <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> was analyzed for interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104) expression using quantitative polymerase chain reaction. Patch testing was negative. Stat6<jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content> mice, in contrast to <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> mice, developed a persistent eczematous dermatitis at sites of calcipotriene application. Clinical and histologic features and high <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 transcript levels were consistent with the spontaneous <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like phenotype seen in Stat6<jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content> mice. At sites of active disease, calcipotriene can worsen a flare of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. In Stat6<jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content> mice, calcipotriene can induce the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like phenotype.<\/jats:p>","DOI":"10.1111\/pde.12187","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T15:56:42Z","timestamp":1374767802000},"page":"574-578","source":"Crossref","is-referenced-by-count":18,"title":["Topical Application of a Vitamin <scp>D<\/scp> Analogue Exacerbates Atopic Dermatitis and Induces the Atopic Dermatitis\u2010like Phenotype in Stat6<scp>VT<\/scp> Mice"],"prefix":"10.1111","volume":"30","author":[{"given":"Matthew J.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Dermatology Indiana University Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia C.","family":"DaSilva\u2010Arnold","sequence":"additional","affiliation":[{"name":"Department of Dermatology Indiana University Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaofang","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Indiana University Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purvi","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Herman B. Wells Center for Pediatric Research Indiana University Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Herman B. Wells Center for Pediatric Research Indiana University Indianapolis Indiana"},{"name":"Department of Microbiology and Immunology Indiana University Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Travers","sequence":"additional","affiliation":[{"name":"Department of Dermatology Indiana University Indianapolis Indiana"},{"name":"Department of Pediatrics Herman B. Wells Center for Pediatric Research Indiana University Indianapolis Indiana"},{"name":"Department of Pharmacology and Toxicology Indiana University Indianapolis Indiana"},{"name":"Richard L. Roudebush Veterans Affairs Medical Center School of Medicine Indiana University Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2010.05.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra074081"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v28.i1.20"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8239-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.11.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901860"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3478"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604575103"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.232"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08601.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1945"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.215459"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12187","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:50:08Z","timestamp":1696027808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,25]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/pde.12187"],"URL":"https:\/\/doi.org\/10.1111\/pde.12187","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,25]]}}}