{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:22:16Z","timestamp":1789363336473,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence of acne in younger children is increasing. Of the acne treatments that the U.S. <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ood and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>rug <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>dministration (<jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>) has approved for ages 12 years and older, it is unclear which medications are being prescribed off\u2010label for this younger patient population. The purpose of this study is to compare the therapies being prescribed to preadolescent patients with acne (defined in this study as ages 7 to 11 years) with those being prescribed to adolescent patients (ages 12 to 18 years) and to determine whether prescribing patterns differ between dermatologists and pediatricians. Leading therapies for the treatment of children with a diagnosis of acne were collected from the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>mbulatory <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>are <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>urvey (<jats:styled-content style=\"fixed-case\">NAMCS<\/jats:styled-content>) from 1993 to 2009. Data were stratified according to age group and physician specialty. Physicians prescribed a wide variety of <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>\u2010approved and off\u2010label medications to preadolescent patients with acne. The leading medications were topical treatments, including adapalene (14.4%), benzoyl peroxide (12.8%), and tretinoin (12.5%). Treatment of this age group differed substantially between specialties, with dermatologists frequently prescribing topical retinoids and primary care physicians preferring antibiotics, particularly oral antibiotics. Limitations included a lack of data on acne severity and morphology through <jats:styled-content style=\"fixed-case\">NAMCS<\/jats:styled-content>, as well as the absence of longitudinal data. With the limited number of <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>\u2010approved treatment options, off\u2010label prescribing for acne in preadolescent patients is common. Furthermore, this study identified a potential knowledge gap between pediatricians based on their prescribing patterns in this patient population.<\/jats:p>","DOI":"10.1111\/pde.12201","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T04:45:02Z","timestamp":1374554702000},"page":"689-694","source":"Crossref","is-referenced-by-count":27,"title":["Treatment of Preadolescent Acne in the United States: An Analysis of Nationally Representative Data"],"prefix":"10.1111","volume":"30","author":[{"given":"Scott A.","family":"Davis","sequence":"first","affiliation":[{"name":"Center for Dermatology Research Department of Dermatology School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura F.","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research Department of Dermatology School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl J.","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research Department of Dermatology School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research Department of Dermatology School of Medicine Wake Forest University Winston\u2010Salem North Carolina"},{"name":"Department of Pathology School of Medicine Wake Forest University Winston\u2010Salem North Carolina"},{"name":"Department of Public Health Sciences School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Cordoro","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California at San Francisco San Francisco California"},{"name":"Department of Pediatrics University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01643.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3079"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1478"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2491"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.07.002"},{"key":"e_1_2_8_7_1","unstructured":"U.S. Food and Drug Administration. 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