{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:09:55Z","timestamp":1768892995738,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adults with psoriasis have a greater risk of developing metabolic syndrome (<jats:styled-content style=\"fixed-case\">MetS<\/jats:styled-content>) and cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>), but few studies have investigated the prevalence of <jats:styled-content style=\"fixed-case\">MetS<\/jats:styled-content> and other risk factors for <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> in children with psoriasis. In an assessor\u2010blinded study, 20 children ages 9\u201317 years with a current or previously documented history of psoriasis involving 5% or more of their body surface area or\u00a0psoriatic arthritis were compared with a cohort of age\u2010 and sex\u2010matched controls with benign nevi, warts, or acne. <jats:styled-content style=\"fixed-case\">MetS<\/jats:styled-content>, our primary endpoint, was defined by the presence of abnormal values in at least three of the following measures: triglycerides, high\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">HDL\u2010C<\/jats:styled-content>), fasting blood glucose (<jats:styled-content style=\"fixed-case\">FBG<\/jats:styled-content>), waist circumference, and blood pressure. Secondary endpoints included high\u2010sensitivity C\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), total cholesterol (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>), and low\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">LDL\u2010C<\/jats:styled-content>). Thirty percent (6\/20) of children with psoriasis met the criteria for <jats:styled-content style=\"fixed-case\">MetS<\/jats:styled-content>, compared with 5% (1\/20) of the control group (p\u00a0&lt;\u00a00.05). Subjects with\u00a0psoriasis had higher mean <jats:styled-content style=\"fixed-case\">FBG<\/jats:styled-content> (91.1\u00a0mg\/dL) than the control group (82.9\u00a0mg\/dL) (p\u00a0=\u00a00.01). There were no statistically significant differences in the other four components of <jats:styled-content style=\"fixed-case\">MetS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BMI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BMI<\/jats:styled-content> percentile, hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TC<\/jats:styled-content>, or <jats:styled-content style=\"fixed-case\">LDL\u2010C<\/jats:styled-content>. The results of this trial demonstrate that children with psoriasis have higher rates of <jats:styled-content style=\"fixed-case\">MetS<\/jats:styled-content> than age\u2010 and sex\u2010matched controls. It may therefore be important to evaluate\u00a0children with psoriasis for components of <jats:styled-content style=\"fixed-case\">MetS<\/jats:styled-content> to prevent future <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> morbidity and mortality.<\/jats:p>","DOI":"10.1111\/pde.12218","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T10:16:14Z","timestamp":1378721774000},"page":"700-705","source":"Crossref","is-referenced-by-count":49,"title":["Prevalence of the Metabolic Syndrome in Children with Psoriatic Disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Ari M.","family":"Goldminz","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine D.","family":"Buzney","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine Boston 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