{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:43:14Z","timestamp":1771476194438,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Netherton syndrome (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>) is a rare autosomal recessive disorder characterized by ichthyosiform scaling, hair abnormalities, and variable atopic features. Mutations in the serine protease inhibitor Kazal type 5 (<jats:italic><jats:styled-content style=\"fixed-case\">SPINK<\/jats:styled-content>5<\/jats:italic>) gene leading to lymphoepithelial Kazal\u2010type\u2010related inhibitor (<jats:styled-content style=\"fixed-case\">LEKTI<\/jats:styled-content>) deficiency cause <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>. Growth retardation is a classic feature of <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>, but growth hormone (<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>) deficiency with subsequent response to <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> therapy is not documented in the literature. It is proposed that a lack of inhibition of proteases due to a deficiency of <jats:styled-content style=\"fixed-case\">LEKTI<\/jats:styled-content> in the pituitary gland leads to the overprocessing of human <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>. Herein we report three patients with <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> who had growth retardation associated with <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> deficiency and responded well to <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> therapy.<\/jats:p>","DOI":"10.1111\/pde.12220","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T10:16:27Z","timestamp":1378721787000},"page":"90-94","source":"Crossref","is-referenced-by-count":19,"title":["Netherton Syndrome Associated with Growth Hormone Deficiency"],"prefix":"10.1111","volume":"31","author":[{"given":"Banu K\u00fc\u00e7\u00fckemre","family":"Ayd\u0131n","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Endocrinology Unit Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firdevs","family":"Ba\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Endocrinology Unit Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Tamay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pediatric Allergy Unit Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcrkan","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pediatric Allergy Unit Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"S\u00fcleyman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pediatric Allergy Unit Istanbul 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