{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:58:19Z","timestamp":1778522299119,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recessive dystrophic epidermolysis bullosa (<jats:styled-content style=\"fixed-case\">RDEB<\/jats:styled-content>) is a genetic disorder in which mutations in collagen <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content>, the main component of the anchoring fibril, lead to skin fragility and to the development of acute and chronic wounds. Wound care and dressing changes are an important part of the daily lives of individuals with <jats:styled-content style=\"fixed-case\">RDEB<\/jats:styled-content>. Ideal wound care should improve wound healing, minimize pain, and improve quality of life. The objective of the current study was to review wound care options that might be used in a patient with <jats:styled-content style=\"fixed-case\">RDEB<\/jats:styled-content> and calculate the cost of these various options based on publicly available pricing of wound care products. There is a wide range of costs for wound care options in patients with <jats:styled-content style=\"fixed-case\">RDEB<\/jats:styled-content>. For example, a 1\u2010day supply of dressing for a neonate boy with <jats:styled-content style=\"fixed-case\">RDEB<\/jats:styled-content> ranges from $10.64 for the least expensive option to $127.54 for the most expensive option. Wound care in patients with severe, generalized <jats:styled-content style=\"fixed-case\">RDEB<\/jats:styled-content> has not only a significant economic effect, but also directly affects quality of life in this patient population. Although randomized controlled trials evaluating different wound care products in patients with <jats:styled-content style=\"fixed-case\">RDEB<\/jats:styled-content> are lacking, small studies and expert opinion support the use of specialized nonadherent dressings that minimize skin trauma and promote wound healing. Until there is a cure, prospective studies are needed to assess pain, quality of life, and wound healing associated with the use of specialized wound care products for this life\u2010altering condition.<\/jats:p>","DOI":"10.1111\/pde.12243","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T07:24:49Z","timestamp":1384413889000},"page":"33-37","source":"Crossref","is-referenced-by-count":25,"title":["Evaluation of Wound Care Options in Patients with Recessive Dystrophic Epidermolysis Bullosa: A Costly Necessity"],"prefix":"10.1111","volume":"31","author":[{"given":"Anna Yasmine","family":"Kirkorian","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Medicine and Dentistry of New Jersey Robert Wood Johnson Somerset New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole A.","family":"Weitz","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons Columbia University New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brook","family":"Tlougan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Joseph M. 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