{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:47:46Z","timestamp":1790192866719,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hutchinson\u2013<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ilford progeria syndrome (<jats:styled-content style=\"fixed-case\">HGPS<\/jats:styled-content>) is a rare, uniformly fatal, premature aging disease with distinct dermatologic features. We sought to identify and describe the initial skin and hair findings as potential diagnostic signs of the disease. We performed a chart review of the structured initial intake histories of 39 individuals with <jats:styled-content style=\"fixed-case\">HGPS<\/jats:styled-content> enrolled in clinical trials from 2007 to 2010 at <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>oston <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hildren's <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital, limited to cutaneous history from birth to 24\u00a0months. Medical photographs were provided through the clinical trials and the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rogeria <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>esearch <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>oundation <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical and <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>esearch <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>atabase at <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>rown <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter for <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>erontology and <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealthcare <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>esearch. All 39 patients reported skin and hair abnormalities within the first 24\u00a0months of life. Pathologies included sclerodermoid change, prominent superficial veins, dyspigmentation, and alopecia. The mean age of presentation for each finding was &lt;12\u00a0months. The most frequently reported skin feature was sclerodermoid change, which commonly involved the abdomen and bilateral lower extremities. Prominent superficial vasculature manifested as circumoral cyanosis and pronounced veins on the scalp and body. Hypo\u2010 and hyperpigmentation were observed over areas of sclerodermoid change. Scalp alopecia progressed in a distinct pattern, with preservation of the hair over the midscalp and vertex areas for the longest period of time. <jats:styled-content style=\"fixed-case\">HGPS<\/jats:styled-content> has distinct cutaneous manifestations during the first 2\u00a0years of life that may be the first signs of disease. Awareness of these findings could expedite diagnosis.<\/jats:p>","DOI":"10.1111\/pde.12284","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T08:35:52Z","timestamp":1390552552000},"page":"196-202","source":"Crossref","is-referenced-by-count":40,"title":["Initial Cutaneous Manifestations of Hutchinson\u2010Gilford Progeria Syndrome"],"prefix":"10.1111","volume":"31","author":[{"given":"Jillian F.","family":"Rork","sequence":"first","affiliation":[{"name":"Department of Dermatology Boston Children's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer T.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Boston Children's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie B.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Boston Children's Hospital Harvard Medical School Boston Massachusetts"},{"name":"Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School Boston Massachusetts"},{"name":"Department of Pediatrics Hasbro Children's Hospital Warren Alpert Medical School of Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Kleinman","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Boston Children's Hospital Harvard Medical School Boston Massachusetts"},{"name":"Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Kieran","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Boston Children's Hospital Harvard Medical School Boston Massachusetts"},{"name":"Division of Pediatric Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn G.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Boston Children's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706898"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1356"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31346"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01629"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084125"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202529109"},{"key":"e_1_2_8_8_1","volume-title":"Hutchinson\u2010Gilford progeria syndrome. 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