{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:58:34Z","timestamp":1784591914840,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the prognosis of maculopapular cutaneous mastocytosis (<jats:styled-content style=\"fixed-case\">MPCM<\/jats:styled-content>), also referred to as urticaria pigmentosa, is often benign, clinicians lack evidence to reliably predict those at risk of associated systemic manifestations. We sought to elucidate clinical markers of disease severity to provide better treatment and prognostic information for individuals with <jats:styled-content style=\"fixed-case\">MPCM<\/jats:styled-content>. A retrospective chart review querying characteristics of children diagnosed with <jats:styled-content style=\"fixed-case\">MPCM<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>mory <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ermatology <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linic was performed. Follow\u2010up was obtained through a clinical encounter or telephone interview. Linear regression was used to determine predictors of the number of <jats:styled-content style=\"fixed-case\">MPCM<\/jats:styled-content>\u2010related systemic symptoms. Of 67 subjects, 57% were male, and the mean age of onset was 4.5\u00a0months. The maximum number of <jats:styled-content style=\"fixed-case\">MPCM<\/jats:styled-content> lesions was 1 to 10 in 16%, 11 to 30 in 33%, 31 to 50 in 25%, 51 to 100 in 6%, and more than 100 in 20% of subjects. For their <jats:styled-content style=\"fixed-case\">MPCM<\/jats:styled-content> lesions, 46% of subjects reported itching, 34% flushing, and 25% blistering. Reported systemic symptoms included diarrhea (22%), abdominal pain (15%), wheezing or dyspnea (13%), vomiting (10%), bone pain (10%), headaches (8%), cough (10%), rhinorrhea (8%), irritability (6%), and anaphylaxis (1.5%). In a multivariate linear regression analysis, the maximum number of <jats:styled-content style=\"fixed-case\">MPCM<\/jats:styled-content> lesions (p\u00a0=\u00a00.02) and the number of skin symptoms (p\u00a0&lt;\u00a00.01) were statistically significant predictors of the number of systemic symptoms, controlling for age of onset, body sites involved, and sex. The correlation between cutaneous findings and symptomatology could aid clinicians in identifying individuals with <jats:styled-content style=\"fixed-case\">MPCM<\/jats:styled-content> who might warrant systemic evaluation and therapy.<\/jats:p>","DOI":"10.1111\/pde.12291","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T06:46:46Z","timestamp":1393397206000},"page":"271-275","source":"Crossref","is-referenced-by-count":29,"title":["Severity of Cutaneous Findings Predict the Presence of Systemic Symptoms in Pediatric Maculopapular Cutaneous Mastocytosis"],"prefix":"10.1111","volume":"31","author":[{"given":"Meredith","family":"Barnes","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Van","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"DeLong","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie P.","family":"Lawley","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Emory University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01807.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328355b248"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00560.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922808318344"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22125"},{"key":"e_1_2_5_7_1","first-page":"320","article-title":"Pediatric cutaneous mastocytosis: a review of 180 patients","volume":"7","author":"Ben\u2010Amitai D","year":"2005","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00830.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02812.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03005.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.98"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/11588890-000000000-00000"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1980.tb01568.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198708000-00005"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/80.1.26"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01569.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12291","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T19:30:39Z","timestamp":1696015839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,26]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/pde.12291"],"URL":"https:\/\/doi.org\/10.1111\/pde.12291","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,26]]}}}