{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:36:22Z","timestamp":1787877382625,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T00:00:00Z","timestamp":1402444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>), the most common cutaneous T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>), is rare in childhood. The prognosis and response to treatment are poorly described in children. The objective of the current study was to evaluate the response to phototherapy in a pediatric cohort. A retrospective cohort study of all patients diagnosed with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> before the age of 18 years and referred to the regional <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> phototherapy service was performed between January 1990 and April 2012. Twenty\u2010eight patients were identified (13 boys, 15 girls). The mean age at presentation was 11.6\u00a0\u00b1\u00a03.9 years. The hypopigmented variant was noted in 79% of patients. All patients had stage I disease (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\u00a0=\u00a010, <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content>\u00a0=\u00a017, unknown\u00a0=\u00a01). The median follow\u2010up after diagnosis was 43\u00a0months (range 6\u2013274\u00a0mos). Narrowband ultraviolet B (Nb<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>; 311\u00a0nm) was used as first\u2010line phototherapy in 18 patients and psoralen (bath) plus ultraviolet A (<jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>) was used in 8 patients. Complete or partial response was observed in 19 of 22 patients (86%). A further course of phototherapy was required in 7 of 12 patients (58%) treated with Nb<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> after a median of 4\u00a0months (range 4\u201329\u00a0mos). A further course of phototherapy was required in four of eight patients (50%) successfully treated with <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> after a median of 45.5\u00a0months (range 30\u201387\u00a0mos). No disease progression was noted over the follow\u2010up (median 43\u00a0mos). The majority of patients in our cohort had hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>. Phototherapy offers an effective option for treatment of childhood <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, although the period of remission may be greater in patients treated with <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pde.12338","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T07:56:20Z","timestamp":1402473380000},"page":"459-464","source":"Crossref","is-referenced-by-count":59,"title":["Childhood Mycosis Fungoides: Experience of 28 Patients and Response to Phototherapy"],"prefix":"10.1111","volume":"31","author":[{"given":"Philip M.","family":"Laws","sequence":"first","affiliation":[{"name":"Department of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil H.","family":"Shear","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pope","sequence":"additional","affiliation":[{"name":"Section of Dermatology Division of Paediatric Medicine Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08794.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04383.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11780"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70243-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2009.08091"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.057"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0630"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.89.8.1240"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.7.854"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21500.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01129.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)70030-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05698.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.80"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.01.025"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124073"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2012.00683.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12338","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:56:48Z","timestamp":1695477408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,11]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/pde.12338"],"URL":"https:\/\/doi.org\/10.1111\/pde.12338","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,11]]}}}