{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T12:04:30Z","timestamp":1743422670818},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne is occurring more frequently in younger age groups, but most available treatments are considered off\u2010label in young children. As the epidemiology of acne has changed to include younger children over the past 20\u00a0years, neither regulators, pharmaceutical companies, nor clinicians have understood the need or value of obtaining regulatory sanctions for problems physicians have managed using clinical judgment. The objective of this study was to analyze the frequency of off\u2010label acne treatment according to age and other demographic factors. We searched the National Ambulatory Medical Care Survey from 1993 to 2010 for visits in children younger than 12 years of age for the diagnosis of <jats:italic>International Classification of Diseases, Ninth Revision<\/jats:italic>, code 706.1. We tabulated leading acne treatments and assessed factors associated with off\u2010label prescribing. Off\u2010label but appropriate acne treatments were used in 29% of acne visits for children younger than 12 years of age. Dermatologists were more likely than pediatricians to prescribe off\u2010label treatment (p\u00a0&lt;\u00a00.001). The most frequently used off\u2010label treatments were topical retinoids, followed by oral antibiotics. There was no significant trend in the rate of off\u2010label prescribing over time (p\u00a0=\u00a00.40). Off\u2010label treatment is well within the standard of care for young children with acne. More data on the use of topical retinoids in young children will improve our understanding of their use, which may help optimize treatment outcomes for children with acne.<\/jats:p>","DOI":"10.1111\/pde.12379","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T08:27:19Z","timestamp":1402648039000},"page":"551-555","source":"Crossref","is-referenced-by-count":4,"title":["Common Use of Prescription Off\u2010Label Acne Therapy in Children Younger Than 12\u00a0Years Old"],"prefix":"10.1111","volume":"31","author":[{"given":"Sonal A.","family":"Parikh","sequence":"first","affiliation":[{"name":"Department of Dermatology Center for Dermatology Research Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center for Dermatology Research Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Krowchuk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center for Dermatology Research Wake Forest School of Medicine Winston\u2010Salem North Carolina"},{"name":"Department of Pediatrics Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Center for Dermatology Research Wake Forest School of Medicine Winston\u2010Salem North Carolina"},{"name":"Department of Pathology Wake Forest School of Medicine Winston\u2010Salem North Carolina"},{"name":"Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01643.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0490B"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3041"},{"key":"e_1_2_6_6_1","unstructured":"Drugs@FDA.FDA approved drug products [online]. 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