{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:41:22Z","timestamp":1773877282368,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Morphologic heterogeneity among melanocytic proliferations is a common challenge in the diagnosis of melanoma. In particular, atypical melanocytic lesions in children, adolescents, and young adults may be difficult to classify because of significant morphologic overlap with melanoma. Recently a four\u2010probe fluorescence in situ hybridization (\n                    <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>\n                    ) protocol to detect chromosomal abnormalities in chromosomes 6 and 11 has shown promise for improving the classification of melanocytic lesions. We sought to determine the correlation between\n                    <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>\n                    results, morphology, and clinical outcomes in a series of challenging melanocytic proliferations in young patients. We retrospectively performed the standard four\u2010probe\n                    <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>\n                    analysis on 21 melanocytic neoplasms from 21 patients younger than 25 years of age (range 5\u201325 years, mean 14.6 years) from Stanford University Medical Center who were prospectively followed for a median of 51\u00a0months (range 1\u2013136\u00a0months). The study cohort included patients with 5 confirmed melanomas, 2 melanocytic tumors of uncertain malignant potential (Mel\n                    <jats:styled-content style=\"fixed-case\">TUMP<\/jats:styled-content>\n                    s), 10 morphologically challenging atypical Spitz tumors (\n                    <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>\n                    s), and 4 typical Spitz nevi.\n                    <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>\n                    detected chromosomal aberrations in all five melanomas and in one Mel\n                    <jats:styled-content style=\"fixed-case\">TUMP<\/jats:styled-content>\n                    , in which the patient developed subsequent lymph node and distant metastasis. All 10\n                    <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>\n                    s, 4 Spitz nevi, and 1 of 2 Mel\n                    <jats:styled-content style=\"fixed-case\">TUMP<\/jats:styled-content>\n                    s were negative for significant gains or losses in chromosomes 6 and 11q. Our findings demonstrated a strong correlation between positive\n                    <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>\n                    results and the histomorphologic impression of melanoma. This finding was also true for the Mel\n                    <jats:styled-content style=\"fixed-case\">TUMP<\/jats:styled-content>\n                    with poor clinical outcome. Therefore\n                    <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>\n                    may serve as a helpful adjunct in the classification of controversial melanocytic tumors in young patients.\n                  <\/jats:p>","DOI":"10.1111\/pde.12382","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T04:27:22Z","timestamp":1402633642000},"page":"561-569","source":"Crossref","is-referenced-by-count":18,"title":["Fluorescence In Situ Hybridization Analysis of Atypical Melanocytic Proliferations and Melanoma in Young Patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Emilia H.","family":"DeMarchis","sequence":"first","affiliation":[{"name":"School of Medicine Stanford University Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Swetter","sequence":"additional","affiliation":[{"name":"Pigmented Lesion and Melanoma Program Department of Dermatology Stanford University Medical Center Stanford California USA"},{"name":"Veterans Affairs Palo Alto Health Care System Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charay D.","family":"Jennings","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Medical Center Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinah","family":"Kim","sequence":"additional","affiliation":[{"name":"Pigmented Lesion and Melanoma Program Department of Dermatology Stanford University Medical Center Stanford California USA"},{"name":"Department of Pathology Stanford University Medical Center Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"157","volume-title":"Cancer incidence and survival among children and adolescents: United States SEER Program 1975\u20131995","author":"Smith MA","year":"1999"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28289"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31824e3852"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22818"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.04.008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/2009-0503-RA.1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0087"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961104)68:3<317::AID-IJC9>3.0.CO;2-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02928.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.228"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"830","DOI":"10.5858\/2011-0048-RAIR.1","article-title":"Update on fluorescence in situ hybridization","volume":"135","author":"Gerami P","year":"2011","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a1ef36"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182753de6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00787.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.01078.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31820393ee"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2011.01.011"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.386"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822d5ff8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e318271a5cb"},{"key":"e_1_2_6_22_1","first-page":"1539","article-title":"Fluorescence in situ hybridization for ambiguous melanocytic tumors","volume":"27","author":"Gammon B","year":"2012","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824b1efd"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000160"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03984.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0330-OA"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0673-OA"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12382","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.12382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:03:17Z","timestamp":1695470597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,13]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/pde.12382"],"URL":"https:\/\/doi.org\/10.1111\/pde.12382","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718449272.793499647","asserted-by":"object"}]},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,13]]}}}