{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:24:53Z","timestamp":1789604693291,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Oxybutynin for treating hyperhidrosis in children has been evaluated only in short\u2010term studies. We aimed to investigate the long\u2010term effects of oxybutynin in treating children with palmar and plantar hyperhidrosis who had not undergone surgery and who were monitored for at least 6\u00a0months (median 19.6\u00a0mos). A cohort of 97 patients was evaluated retrospectively, with particular attention to 59 children (ages 4\u201314 yrs) who were treated for longer than 6\u00a0months. Their quality of life (\n                    <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>\n                    ) was evaluated using a validated clinical questionnaire before and after 6\u00a0weeks of pharmacologic therapy. A self\u2010assessment of hyperhidrosis was performed after 6\u00a0weeks and after the last consultation. By their final office visit, more than 91% of the children with hyperhidrosis treated with oxybutynin experienced moderate or great improvement in their level of sweating and 94.9% experienced improvement in\n                    <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>\n                    . More than 90% of children reported improvement of hyperhidrosis at other sites. Dry mouth was the most common side effect. Oxybutynin appears to be an effective treatment option for children with hyperhidrosis, and positive results are maintained over the long term (median 19.6\u00a0mos).\n                  <\/jats:p>","DOI":"10.1111\/pde.12385","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T07:14:13Z","timestamp":1418195653000},"page":"663-667","source":"Crossref","is-referenced-by-count":46,"title":["Long\u2010Term Efficacy of Oxybutynin for Palmar and Plantar Hyperhidrosis in Children Younger than 14 Years"],"prefix":"10.1111","volume":"32","author":[{"given":"Nelson","family":"Wolosker","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"},{"name":"Vascular and Endovascular Division Department of Surgery School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-6773","authenticated-orcid":false,"given":"Marcelo P.","family":"Teivelis","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Krutman","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael P.","family":"de Paula","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Schvartsman","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Kauffman","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R. M.","family":"de Campos","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"},{"name":"Division of Thoracic Surgery Hospital das Clinicas, University of S\u00e3o Paulo and Division of Thoracic Surgery Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Puech\u2010Le\u00e3o","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Division Department of Surgery School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32334.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2012.01751.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.01.105"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5040821"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1337117"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.10.068"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.3.506-a"},{"key":"e_1_2_6_9_1","first-page":"326","article-title":"Oxybutynin: dry days for patients with hyperhidrosis","volume":"64","author":"Mijnhout GS","year":"2006","journal-title":"Neth J Med"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.8.1065"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0128-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05746.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2011.06.007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000300005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.12.039"},{"key":"e_1_2_6_16_1","first-page":"559","article-title":"Oxybutynin for treatment of nocturnal enuresis in children","volume":"57","author":"Friedman B\u2010C","year":"2011","journal-title":"Can Fam Physician"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12142"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00895-6"},{"key":"e_1_2_6_19_1","first-page":"151","article-title":"Oxybutynin extended release for the management of overactive bladder: a clinical review","volume":"3","author":"Arisco AM","year":"2009","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322010000600004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1679-45082012000400002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2010.06.002"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.252015"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12385","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T07:13:28Z","timestamp":1696144408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,10]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/pde.12385"],"URL":"https:\/\/doi.org\/10.1111\/pde.12385","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,10]]}}}