{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:47:12Z","timestamp":1780487232574,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Subcutaneous panniculitis\u2010like T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content>) is a type of skin lymphoma. Pleomorphic T\u2010cells infiltrate the subcutaneous tissue and mimic lobular panniculitis. We report a case occurring in a 12\u2010year\u2010old Chinese boy who presented with multiple indolent erythematous subcutaneous nodules on both extremities without systemic symptoms. He had a protracted course of multiple erythematous subcutaneous nodules for 1\u00a0year and underwent biopsy of lesional skin for histology and T\u2010cell receptor (<jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>) gene analysis. Histopathology showed infiltration of medium to large atypical pleomorphic cells involving the subcutis with characteristic rimming of fat spaces. <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> gene rearrangement shows monoclonal rearrangements of the <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> \u03b2 and \u03b3 chains. Immunophenotypic studies showed that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 were strongly and diffusely positive in lesional cells and that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56 was focally positive. In contrast, these cells were negative for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68. The combined morphology, characteristic histologic features, and positive T\u2010CR gene rearrangement supported a diagnosis of <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content>. He is being treated with combination chemotherapy of cyclophosphamide, doxorubicin, vincristine, and prednisolone.<\/jats:p>","DOI":"10.1111\/pde.12452","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T08:03:13Z","timestamp":1424937793000},"page":"526-532","source":"Crossref","is-referenced-by-count":23,"title":["Subcutaneous Panniculitis\u2010Like T\u2010Cell Lymphoma in Children: A Review of the Literature"],"prefix":"10.1111","volume":"32","author":[{"given":"Zhi Li","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Dermatology Jinling Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jinling Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jinling Hospital Southern Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZongHui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jinling Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200106000-00008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-008-1002-y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00305.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01658.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24638"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/639240"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0202-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513815.2010.494703"},{"key":"e_1_2_6_10_1","first-page":"679","article-title":"Subcutaneous panniculitis\u2010like T\u2010cell lymphoma in a 19\u2010month\u2010old boy: a case report","volume":"34","author":"Raji\u0107 L","year":"2010","journal-title":"Coll Antropol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1252"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00043426-199901000-00008","article-title":"Subcutaneous panniculitic T\u2010cell lymphoma developing in a child with idiopathic myelofibrosis","volume":"21","author":"Hung IJ","year":"1999","journal-title":"J Pediatr Hematol Oncol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)00746-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513819409023334"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.045"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600783619"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705527"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2011.06.016"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513815.2012.701264"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2014.896062"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199101000-00002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2008.05.008"},{"key":"e_1_2_6_24_1","first-page":"83","article-title":"WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview","volume":"102","author":"Sabattini E","year":"2010","journal-title":"Pathologica"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20502"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12452","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:13:05Z","timestamp":1696025585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,26]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/pde.12452"],"URL":"https:\/\/doi.org\/10.1111\/pde.12452","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,26]]}}}