{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T21:15:27Z","timestamp":1769375727984,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>An association between juvenile xanthogranuloma (JXG<\/jats:styled-content>), neurofibromatosis type 1 (NF<\/jats:styled-content>1), and juvenile myelomonocytic leukemia (JMML<\/jats:styled-content>) has been described in the literature but has only been documented in approximately 20 cases. We diagnosed a patient with NF<\/jats:styled-content>1 at 25\u00a0months of age, before any cutaneous stigmata of this disease had appeared, because we decided to screen for the NF<\/jats:styled-content>1<\/jats:italic> gene mutation because of his presentation with multiple JXG<\/jats:styled-content>s and moderate macrocephaly (2.5 standard deviations) at 9\u00a0months of age and JMML<\/jats:styled-content> diagnosed at 20\u00a0months of age. The child is well today after treatment with chemotherapy and allogenic bone marrow transplantation. With increased awareness, patients with JXG<\/jats:styled-content> and NF<\/jats:styled-content>1 who develop symptoms possibly related to JMML<\/jats:styled-content>, such as paleness, skin bleeding, cough, unexplained fever, and hepatosplenomegaly, should be further evaluated. We also emphasize that multiple JXG<\/jats:styled-content> lesions can be an early marker of NF<\/jats:styled-content>1.<\/jats:p>","DOI":"10.1111\/pde.12478","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T14:17:39Z","timestamp":1418739459000},"source":"Crossref","is-referenced-by-count":24,"title":["Neurofibromatosis Type 1 Diagnosed in a Child Based on Multiple Juvenile Xanthogranulomas and Juvenile Myelomonocytic Leukemia"],"prefix":"10.1111","volume":"32","author":[{"given":"Sune R. R.","family":"Jans","sequence":"first","affiliation":[{"name":"Department of Pediatrics Roskilde Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckhard","family":"Schomerus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Bygum","sequence":"additional","affiliation":[{"name":"Department of Dermatology Odense University Hospital Odense Denmark"},{"name":"Department of Allergy Centre Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1504","article-title":"Xantholeukemia in infants & Recklinghausen's neurofibromatosis","volume":"34","author":"Royer P","year":"1958","journal-title":"Sem Hop"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017974"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000135282.39550.99"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06958.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2011.08.007"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21219.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.162"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1997)9:4<366::AID-HUMU12>3.0.CO;2-0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.1.267.413a31_267_272"},{"key":"e_1_2_5_11_1","first-page":"268","article-title":"Myelodysplastic syndromes: the pediatric point of view","volume":"80","author":"Locatelli F","year":"1995","journal-title":"Haematologica"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1001\/archderm.1995.01690200040007","article-title":"Juvenile xanthogranuloma, neurofibromatosis and juvenile chronic myelogenous leukemia. World statistical analysis","volume":"131","author":"Zvulunov A","year":"1995","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.6434"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21201.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.2.459"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.132.11.1390"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12478","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:52:51Z","timestamp":1696193571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,16]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/pde.12478"],"URL":"https:\/\/doi.org\/10.1111\/pde.12478","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,16]]}}}