{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:23:53Z","timestamp":1789604633998,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary hyperhidrosis, although extensively documented in adults, typically has onset that dates back to early childhood. It is an unpleasant and socially disabling problem for the affected child, but little attention has been paid to the disease in adolescents. The objective of the current study was to evaluate the effectiveness of botulinum toxin type A (BTXA) in adolescents with primary palmar and axillary hyperhidrosis and to determine its effect on quality of life and social isolation. Thirty\u2010five individuals (17 girls, 18 boys) with moderate to severe palmar and axillary hyperhidrosis were treated with BTXA (onabotulinum). Patients were examined at baseline and 6\u00a0months after treatment. The Hyperhidrosis Disease Severity Scale (<jats:styled-content style=\"fixed-case\">HDSS<\/jats:styled-content>) was used to evaluate disease severity and the Children's Dermatology Life Quality Index (<jats:styled-content style=\"fixed-case\">CDLQI<\/jats:styled-content>) was used to assess quality of life. The University of California at Los Angeles loneliness scale (<jats:styled-content style=\"fixed-case\">UCLA<\/jats:styled-content> version 3) was used to assess personal perception of loneliness and social isolation. The median age of the participants was 14\u00a0years, and 48.6% were female. Twenty\u2010one had palmar hyperhidrosis, and 14 had axillary hyperhidrosis. Total <jats:styled-content style=\"fixed-case\">CDLQI<\/jats:styled-content> and social isolation scores decreased significantly after treatment with BTXA (both p\u00a0&lt;\u00a00.001). There was a significant difference between pre\u2010 and post\u2010treatment levels of severity of hyperhidrosis. No statistically significant difference was documented for <jats:styled-content style=\"fixed-case\">CDLQI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UCLA<\/jats:styled-content> scores between boys and girls. Treatment of hyperhidrosis with BTXA resulted in improvement in quality of life, social skills, and activities.<\/jats:p>","DOI":"10.1111\/pde.12480","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T03:28:36Z","timestamp":1419910116000},"page":"226-230","source":"Crossref","is-referenced-by-count":16,"title":["Quality of Life and Social Isolation in Greek Adolescents with Primary Focal Hyperhidrosis Treated with Botulinum Toxin Type A: A Case Series"],"prefix":"10.1111","volume":"32","author":[{"given":"Anargyros","family":"Kouris","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Armyra","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Stefanaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"2nd Department of Psychiatry Attikon University Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polixeni","family":"Karimali","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kontochristopoulos","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Andreas Sygros Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.040"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00782.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092285"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32334.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.119507"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00732.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.029"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04173.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33192.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb16953.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12437"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6601_2"},{"key":"e_1_2_6_14_1","unstructured":"KafetsiosK. 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