{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:37:52Z","timestamp":1790127472362,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Agnes Varis Charitable Trust"},{"DOI":"10.13039\/100002077","name":"Epidermolysis Bullosa Medical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002077","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jackson Gabriel Silver Foundation"},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1 RR025744"],"award-info":[{"award-number":["UL1 RR025744"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pruritus is a common complication in patients with epidermolysis bullosa (<jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>). There is limited published data about the treatments that individuals with <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content> use for pruritus. The objective of the current study was to determine quantitatively which treatments individuals with <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content> have used for pruritus and to evaluate the perceived effectiveness of these treatments in pruritus relief. A questionnaire was developed to evaluate the treatments and therapies used for pruritus in patients of all ages and for all types of <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>. Questions about bathing products, moisturizers, topical products, oral medications, dressings, and alternative therapies were included. A 5\u2010point <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ikert scale (\u22122\u00a0=\u00a0relieves itch a lot, \u22121\u00a0=\u00a0relieves itch a little, 0\u00a0=\u00a0no change, 1\u00a0=\u00a0increases itch a little, 2\u00a0=\u00a0increases itch a lot) was used to evaluate perceived effectiveness. Patients from seven <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orth <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content> centers were invited to participate. Greasy ointments (53.4%), lotions (45.2%), creams (40.4%), and oral hydroxyzine (39.0%) were the most frequently used treatments for pruritus. Treatments that were used frequently and perceived to be the most effective included creams (mean\u00a0=\u00a0\u22121.1), topical prescription corticosteroids (mean\u00a0=\u00a0\u22121.0), oils (mean\u00a0=\u00a0\u22120.9), oral hydroxyzine (mean\u00a0=\u00a0\u22120.9), topical diphenhydramine (mean\u00a0=\u00a0\u22120.9), and vaporizing rub (menthol, camphor, eucalyptus) (mean\u00a0=\u00a0\u22120.9). Systemic opioids (mean\u00a0=\u00a00.3), adherent bandages (mean\u00a0=\u00a00.3), and bleach baths (mean\u00a0=\u00a00.2) slightly increased pruritus. Randomized controlled trials of therapies will be necessary to develop evidence\u2010based recommendations for control of pruritus in individuals with <jats:styled-content style=\"fixed-case\">EB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pde.12486","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T03:34:43Z","timestamp":1419910483000},"page":"628-634","source":"Crossref","is-referenced-by-count":37,"title":["Evaluation of Treatments for Pruritus in Epidermolysis Bullosa"],"prefix":"10.1111","volume":"32","author":[{"given":"Christina","family":"Danial","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasidat","family":"Adeduntan","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Gorell","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne W.","family":"Lucky","sequence":"additional","affiliation":[{"name":"Division of General and Community Pediatrics Cincinnati Children's Hospital Medical Center Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Paller","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine Northwestern University Chicago Illinois"},{"name":"Department of Pediatrics Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Bruckner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Colorado School of Medicine Aurora Colorado"},{"name":"Department of Pediatrics University of Colorado School of Medicine Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pope","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly D.","family":"Morel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Columbia University Medical Center New York New York"},{"name":"Department of Pediatrics Columbia University Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moise L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dell Children's Medical Center of Central Texas Austin Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S.","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred T.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.903"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12262"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.01.016"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2010.01.008"},{"key":"e_1_2_6_7_1","unstructured":"Stanford University Epidermolysis Bullosa Studies & Clinical Trials[online]. 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