{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:13:30Z","timestamp":1792167210888,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Smith\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>agenis syndrome (<jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content>) is characterized by distinctive facial and skeletal features, developmental delay, cognitive impairment, and behavioral abnormalities, including self\u2010injurious behaviors. We aimed to investigate whether cutaneous features are common in <jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content>. We performed a complete skin examination in 20 young <jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content> patients. Skin features secondary to self\u2010injurious behavior, such as bites, abrasions, dystrophic scars, limited spots of hyperkeratosis, anomalies of the nails, and whitlows, were found in the majority of patients. Acral pachydermia and fissured plantar keratoderma were common. Xerosis was constant and associated with extensive keratosis pilaris in the majority of patients. Dermatofibromas were frequent in older patients. The hair was dense and shiny, with an unusual hairline. Eyelash trichomegaly and heavy brows were common, as well as folliculitis on the back. The skin features of <jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content> have rarely been reported in the literature. Some of these are the consequence of neurobehavioral features, but some cutaneous features and abnormalities of appendages have not been reported in other related syndromes. Skin manifestations of <jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content> are varied, sometimes induced by self\u2010injurious behavior and sometimes more specific. It remains to be determined whether the combination of the two kinds of signs could contribute to early diagnosis of the syndrome.<\/jats:p>","DOI":"10.1111\/pde.12517","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T10:11:18Z","timestamp":1423822278000},"page":"337-341","source":"Crossref","is-referenced-by-count":8,"title":["Dermatologic Features of Smith\u2013Magenis Syndrome"],"prefix":"10.1111","volume":"32","author":[{"given":"Morgane","family":"Gu\u00e9rin\u2010Moreau","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of Angers Angers France"},{"name":"L'UNAM University Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Colin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics University Hospital of Angers Angers France"},{"name":"L'UNAM University Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital of Angers Angers France"},{"name":"L'UNAM University Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Andrieux","sequence":"additional","affiliation":[{"name":"Department of Genetics University Hospital of Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"de Leersnyder","sequence":"additional","affiliation":[{"name":"Department of Pediatrics H\u00f4pital Robert Debr\u00e9 University of Paris VII Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Bonneau","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics University Hospital of Angers Angers France"},{"name":"L'UNAM University Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Angers Angers France"},{"name":"L'UNAM University Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"GeneReviews","author":"Smith ACM"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5202009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000228215.32110.89"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960329)62:3<247::AID-AJMG9>3.0.CO;2-Q"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.08.018"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00815.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2006.07.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895-8017(2001)106<0052:COSIBI>2.0.CO;2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895-8017(1999)104<0260:SBAPSB>2.0.CO;2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-011-9092-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34171"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470703"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/505693"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D38JX5F2V2","article-title":"Phenotypic and dermatological manifestations in Down syndrome","volume":"17","author":"Sureshbabu R","year":"2011","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_16_1","first-page":"346","article-title":"Cutaneous signs of trisomy 21","volume":"121","author":"Thomas L","year":"1994","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320460109"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/512864"},{"key":"e_1_2_6_19_1","first-page":"69","article-title":"Management of keratosis pilaris","volume":"118","author":"Gassia V","year":"1991","journal-title":"Ann Dermatol Venereol"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12517","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:03:50Z","timestamp":1696165430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,12]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/pde.12517"],"URL":"https:\/\/doi.org\/10.1111\/pde.12517","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,12]]}}}