{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:57:22Z","timestamp":1788526642016,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>\n \n Nevus anemicus (\n NA<\/jats:styled-content>\n ) is a cutaneous anomaly characterized by pale, well\u2010defined patches with limited vascularization after rubbing. They are largely known to be associated with neurofibromatosis 1 (\n NF<\/jats:styled-content>\n 1) and have received little attention in the literature until recently. We sought to characterize the prevalence and clinical features of patients with\n NA<\/jats:styled-content>\n and\n NF<\/jats:styled-content>\n 1. We conducted an observational prospective study of 99 children with\n NF<\/jats:styled-content>\n 1 at the Hospital Ni\u00f1o Jes\u00fas, Madrid, Spain, from January 1, 2012, through July 31, 2013, and reviewed three other series of patients with\n NF<\/jats:styled-content>\n 1 and\n NA<\/jats:styled-content>\n recently reported. The prevalence of\n NA<\/jats:styled-content>\n in children with\n NF<\/jats:styled-content>\n 1 ranged from 8.8% to 51%, being much more prevalent at younger ages. Prospective studies yielded a higher prevalence than retrospective studies.\n NA<\/jats:styled-content>\n was located most commonly on the trunk, particularly on the anterior chest wall, and was often multiple. Patients with segmental\n NF<\/jats:styled-content>\n 1 or isolated caf\u00e9 au lait spots rarely had\n NA<\/jats:styled-content>\n , and\n NA<\/jats:styled-content>\n was absent in other genodermatoses. The collection of data was not homogeneous in all studies.\n NA<\/jats:styled-content>\n has a high prevalence in individuals with\n NF<\/jats:styled-content>\n 1 patients but seems to be absent in connection with other genodermatoses, therefore its presence can assist in the diagnosis of suspected cases of\n NF<\/jats:styled-content>\n 1. The subtle clinical appearance of\n NA<\/jats:styled-content>\n makes its detection difficult, and physicians involved in the care of children with\n NF<\/jats:styled-content>\n 1 must be aware of its possible presence and significance.\n <\/jats:p>","DOI":"10.1111\/pde.12525","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T01:52:07Z","timestamp":1424224327000},"page":"342-347","source":"Crossref","is-referenced-by-count":28,"title":["Nevus Anemicus: A Distinctive Cutaneous Finding in Neurofibromatosis Type 1"],"prefix":"10.1111","volume":"32","author":[{"given":"Angela","family":"Hern\u00e1ndez\u2010Mart\u00edn","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Infantil del Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Garc\u00eda\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Sureste Arganda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Duat","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Infantil del Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"L\u00f3pez\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Primary Health Care Centre of Soto del Real Soto del Real Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucero","family":"Noguera\u2010Morel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil del Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Torrelo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil del Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90209-N"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb07616.x"},{"key":"e_1_2_6_4_1","first-page":"172","article-title":"National Institutes of Health Consensus Development Conference Statement: neurofibromatosis. 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