{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:09:58Z","timestamp":1778497798364,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periorificial dermatitis (POD) is a rosacea\u2010like papulopustular facial eruption most commonly reported in young adult women. Although POD has been reported in children as young as 6 months of age, there are limited data on the diagnosis and management of POD in pediatric cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All children diagnosed with POD at the Dermatology Clinic at the University of North Carolina at Chapel Hill between June 2002 and March 2014 were included in the current study. Information related to demographics, associated risk factors, treatment prescribed, adverse effects, and response to treatment were obtained from a retrospective analysis of medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 222 children identified, 55.4% were female, 62.2% Caucasian, and the average age at presentation to the clinic was 6.6 years. Although the etiology of POD remains uncertain, 29.3% reported a past medical history of atopic dermatitis, 14.9% reported a history of asthma and 58.1% reported a history of steroid use prior to POD onset. Fifty\u2010nine percent were seen at a clinic visit for follow\u2010up at an average of 3.8 months. Treatment often involved combining oral azithromycin with topical metronidazole or sodium sulfacetamide lotion. Of the patients with documented follow\u2010up, 71.8% experienced complete resolution of POD. Recurrence of POD occurred in children dependent on inhaled steroids or nebulizers. Adverse effects were minimally noted, but included pigmentary changes (1.8%), worsening of symptoms (1.8%), gastrointestinal upset (0.9%), irritant dermatitis (0.9%), and xerosis (0.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study discusses the clinical diagnosis and management of POD in pediatric cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12534","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T13:28:23Z","timestamp":1428326903000},"page":"333-336","source":"Crossref","is-referenced-by-count":29,"title":["Pediatric Periorificial Dermatitis: Clinical Course and Treatment Outcomes in 222 Patients"],"prefix":"10.1111","volume":"32","author":[{"given":"Nikita S.","family":"Goel","sequence":"first","affiliation":[{"name":"Brody School of Medicine East Carolina University Greenville North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig N.","family":"Burkhart","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of North Carolina Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean S.","family":"Morrell","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of North Carolina Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.031"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.09.007"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1957.01550140089014"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1964.01590300031010"},{"key":"e_1_2_5_6_1","first-page":"132","article-title":"Perioral dermatitis in children and adults","volume":"46","author":"Gianotti F","year":"1971","journal-title":"G Ital Dermatol Minerva Dermatol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(99)80018-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3928\/0090-4481-20071201-09"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00979.x"},{"key":"e_1_2_5_10_1","first-page":"317","article-title":"Perioral dermatitis: it's not every rash that occurs around the mouth","volume":"21","author":"Vanderweil SG","year":"2009","journal-title":"Dermatol Nurs"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01651.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03860.x"},{"key":"e_1_2_5_13_1","first-page":"422","article-title":"Perioral dermatitis","volume":"5","author":"Wollenberg A","year":"2011","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70238-B"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1972.tb01590.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05000_14.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12534","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:03:59Z","timestamp":1696165439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,6]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/pde.12534"],"URL":"https:\/\/doi.org\/10.1111\/pde.12534","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,6]]}}}