{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:22:01Z","timestamp":1788970921136,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lasers, 595\u2010nm pulsed dye and 1,064\u2010nm neodymium\u2010doped yttrium aluminum garnet (Nd:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>), have been used successfully for the treatment of infantile hemangiomas (<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s). Recently the use of a topical \u03b2\u2010blocker, specifically timolol maleate, has been promising in the treatment of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s. The objective of this study was to compare the effectiveness of topical timolol 5\u00a0mg\/mL solution with that of combined sequential dual\u2010wavelength laser in the treatment of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s. Sixty children with <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s were divided randomly into two equal groups. Group 1 was treated with applications of timolol drops (5\u00a0mg\/mL) twice daily. Group 2 was treated with sequential pulsed dye and Nd:Yag laser. Treatments were performed every month for a maximum of six sessions. Efficacy was evaluated clinically and by measuring the average hemoglobin level. A significant decrease in the average hemoglobin level was determined in both groups and a dramatic response was observed in superficial hemangiomas in the timolol group. The timolol group received treatment for an average of 4.0\u00a0\u00b1\u00a01.1\u00a0months and the laser group for 5.5\u00a0\u00b1\u00a00.9\u00a0months. The degree of improvement of mixed hemangiomas to laser treatment was greater than that of the timolol group. During 3\u00a0months of follow\u2010up, no further improvement or relapse was reported in either group. Timolol solution is a safe and effective alternative to laser treatment in superficial hemangiomas. In mixed hemangiomas, the combined sequential 595\u2010nm and 1,064\u2010nm dual\u2010wavelength laser provided better results than timolol solution because it penetrated deeply so that deep dermal blood vessels were reached.<\/jats:p>","DOI":"10.1111\/pde.12542","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T07:24:52Z","timestamp":1425540292000},"page":"369-376","source":"Crossref","is-referenced-by-count":28,"title":["Topical Timolol Solution Versus Laser in Treatment of Infantile Hemangioma: A Comparative Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Abeer A.","family":"Tawfik","sequence":"first","affiliation":[{"name":"Dermatology Unit Department of Medical Applications of Lasers National Institute of Laser Enhanced Sciences Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehan","family":"Alsharnoubi","sequence":"additional","affiliation":[{"name":"Pediatrics Unit Department of Medical Applications of Lasers National Institute of Laser Enhanced Sciences Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00626.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21274"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12436"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01664.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10177.x"},{"key":"e_1_2_6_7_1","first-page":"1246","article-title":"Deep periocular infantile capillary hemangiomas responding to topical application of timolol maleate, 0.5% drops","volume":"131","author":"Xue K","year":"2013","journal-title":"J Am Med Assoc Ophthalmol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2012.04425.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.5.628"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.12.010"},{"key":"e_1_2_6_11_1","volume-title":"Aesthetic medicine: art and technique","author":"Prendergast MP","year":"2011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19971201)67:3<353::AID-JCB7>3.0.CO;2-V"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2010.00611.x"},{"key":"e_1_2_6_14_1","first-page":"310","article-title":"Using pulsed dual wavelength 595 and 1064\u00a0nm is more effective in the management of hemangiomas","volume":"9","author":"Saafan AM","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3892\/etm.2013.1176","article-title":"Treatment of superficial infantile hemangiomas with timolol: evaluation of short term efficacy and safety in infants","volume":"6","author":"Linjun YU","year":"2013","journal-title":"Exp Ther Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01685.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12542","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:04:13Z","timestamp":1696165453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/pde.12542"],"URL":"https:\/\/doi.org\/10.1111\/pde.12542","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,5]]}}}