{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T03:19:33Z","timestamp":1768360773571,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T00:00:00Z","timestamp":1429056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) is a common oral ulcerative condition in children. The objective was to describe the clinical features of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> in children with accompanying clinical and laboratory findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 120 patients younger than 18\u00a0years of age (mean age 9.6\u00a0\u00b1\u00a04.3\u00a0years) with three or more oral aphthous ulcers per year between August 2008 and February 2014. Demographic characteristics of the patients, clinical features of the ulcers, and associated clinical and laboratory findings were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean number of aphthae per year was 12.8\u00a0\u00b1\u00a08.5 and the mean duration of the disease was 3.6\u00a0\u00b1\u00a02.9\u00a0years. Minor aphthae were the most common type (87%), papulopustules were the most common accompanying cutaneous lesions (13.3%), and family history of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> was the most common associated factor (35.8%). Genital scarring (p\u00a0=\u00a00.04) and pathergy (p\u00a0=\u00a00.01) were significantly more common in the adolescent group. Pathergy was significantly related to genital scarring (p\u00a0=\u00a00.04) and Beh\u00e7et's disease (p\u00a0=\u00a00.02). There was no association between the number of aphthae per year and the duration of the disease and hematologic and immunologic abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study is consistent with previous reports in terms of clinical features of aphthous ulcers, related diseases, and family history of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>, but no associated laboratory abnormalities were noted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12577","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T10:37:31Z","timestamp":1429094251000},"page":"476-480","source":"Crossref","is-referenced-by-count":14,"title":["Recurrent Aphthous Stomatitis in Childhood and Adolescence: A Single\u2010Center Experience"],"prefix":"10.1111","volume":"32","author":[{"given":"Asuman","family":"G\u00fcrkan","sequence":"first","affiliation":[{"name":"Department of Dermatology Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sare G\u00fclfem","family":"\u00d6zl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0131nar","family":"Alt\u0131ayl\u0131k\u2010\u00d6zer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengi Ece","family":"Kurtul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can Demir","family":"Karacan","sequence":"additional","affiliation":[{"name":"Department of Child Health and Diseases Faculty of Medicine, Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saliha","family":"\u015eenel","sequence":"additional","affiliation":[{"name":"Department of Child Health and Diseases Faculty of Medicine, Yildirim Beyazit University Ankara 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