{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:04:05Z","timestamp":1782795845295,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T00:00:00Z","timestamp":1429056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Previous data suggest that early application of intravenous methylprednisolone pulse therapy (\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MPPT<\/jats:styled-content>\n                      ) may improve the disease course of alopecia areata. The objective of this study was to investigate the outcome of\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MPPT<\/jats:styled-content>\n                      in severe childhood alopecia areata, predominantly with short disease duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighteen children (10 girls, 8 boys) younger than 17\u00a0years old (median age 7.7\u00a0yrs, range 2.1\u201316.5\u00a0yrs) treated with\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MPPT<\/jats:styled-content>\n                      for severe childhood alopecia areata in a referral center for pediatric dermatology over 3\u00a0years (median disease duration 4\u00a0mos, range 1\u201312\u00a0mos) were retrospectively evaluated. Five patients had alopecia areata totalis or universalis and 13 had alopecia multilocularis. The median scalp area affected by alopecia was 60% (range 30%\u2013100%). All patients underwent two or three cycles of\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MPPT<\/jats:styled-content>\n                      at monthly intervals (maximum 500\u00a0mg\/day on three consecutive days).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within 7\u00a0months after the last\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MPPT<\/jats:styled-content>\n                      session, 10 of 18 children had good response (\u226575% of hair regrowth), with eight showing improvement within the first 4 months. Of the remaining eight patients, one had moderate response (50%\u201374% regrowth), three had poor response (1%\u201349% regrowth), and four (all with alopecia areata universalis or totalis) had no response. Seven of the initial 10 good responders experienced relapses, with marked hair loss after the last\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MPPT<\/jats:styled-content>\n                      session. The estimated median time to relapse was 8\u00a0months (95% confidence interval 7, 9\u00a0mos).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">MPPT<\/jats:styled-content>\n                      , even early in the course of disease, did not affect long\u2010term outcome of alopecia areata in our group of severely affected patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.12578","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T05:06:21Z","timestamp":1429074381000},"page":"481-487","source":"Crossref","is-referenced-by-count":31,"title":["High Relapse Rates Despite Early Intervention with Intravenous Methylprednisolone Pulse Therapy for Severe Childhood Alopecia Areata"],"prefix":"10.1111","volume":"32","author":[{"given":"Alexandra","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Pediatric Dermatology University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph M.","family":"Tr\u00fceb","sequence":"additional","affiliation":[{"name":"Center for Dermatology and Hair Diseases Professor Tr\u00fceb Wallisellen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Theiler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dermatology University Children's Hospital Zurich Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Hauser","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Ostschweizer Children's Hospital St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Weibel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dermatology University Children's Hospital Zurich Zurich Switzerland"},{"name":"Department of Dermatology University Hospital Zurich Zurich 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