{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:40:20Z","timestamp":1771065620171,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The epidemiology and demographic profile of acne vulgaris has evolved over the past several decades, with a noted earlier onset occurring in patients as young as 7\u00a0years of age. The combination of a foaming facial wash and a facial moisturizer with a sun protection factor (<jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content>) of 30 is an over\u2010the\u2010counter cleansing and moisturizing regimen for acne\u2010prone skin that has been shown to be safe and tolerable in subjects 12\u00a0years of age and older.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the tolerability of this skin care regimen in children ages 7 to 11\u00a0years with acne\u2010prone skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an open\u2010label, single\u2010center study that investigated the safety and tolerability of these products in subjects 7 to 11\u00a0years of age (ClinicalTrials.gov, <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01909713). Subjects used the foaming wash twice daily and the <jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content> 30 moisturizer once daily. Subjects were assessed for cutaneous tolerability, and satisfaction at baseline and weeks 1 and 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five subjects enrolled and completed the study. The cutaneous tolerability score of most subjects was none when assessed by the investigator and subject or legally authorized representative at weeks 1 and 3. The products were well tolerated and a positive impression for cosmetic acceptability was reported for both products by the study population on the questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports the use of a skin care regimen comprising a wash and a moisturizer in acne\u2010prone patients as young as 7\u00a0years old since these products were safe, well tolerated, and liked by subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12607","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T07:46:41Z","timestamp":1431589601000},"page":"501-505","source":"Crossref","is-referenced-by-count":5,"title":["Tolerability of a Skin Care Regimen Formulated for Acne\u2010Prone Skin in Children"],"prefix":"10.1111","volume":"32","author":[{"given":"David","family":"Hensley","sequence":"first","affiliation":[{"name":"Metroplex Dermatology Arlington Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew H.","family":"Meckfessel","sequence":"additional","affiliation":[{"name":"Galderma Laboratories, L.P. Fort Worth Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01643.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.07.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0490B"},{"key":"e_1_2_6_5_1","first-page":"28","article-title":"The role of skin care as an integral component in the management of acne vulgaris: part 2: tolerability and performance of a designated skin care regimen using a foam wash and moisturizer SPF 30 in patients with acne vulgaris undergoing active treatment","volume":"6","author":"Del Rosso JQ","year":"2013","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_6_1","first-page":"264","article-title":"Assessment of hypoallergenicity of ten skincare products","volume":"13","author":"Brandt S","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_7_1","volume-title":"Data on file","author":"Galderma Laboratories"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111340"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/0128071-200910001-00001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304110-00005"},{"key":"e_1_2_6_11_1","first-page":"542","article-title":"The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic mechanisms of acne: a systemic review of the literature","volume":"12","author":"Brandt S","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32835c2b57"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.891"},{"key":"e_1_2_6_14_1","first-page":"18","article-title":"Acne vulgaris and the epidermal barrier","volume":"6","author":"Thiboutot D","year":"2013","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_15_1","first-page":"19","article-title":"The role of skin care as an integral component in the management of acne vulgaris: part 1: the importance of cleanser and moisturizer ingredients, design, and product selection","volume":"6","author":"Del Rosso JQ","year":"2013","journal-title":"J Clin Aesthet Dermatol"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:12:22Z","timestamp":1696025542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/pde.12607"],"URL":"https:\/\/doi.org\/10.1111\/pde.12607","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,14]]}}}