{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:55:30Z","timestamp":1790016930199,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Divided nevus is a rare entity that has been described for a special appearance of congenital melanocytic nevi (CMN<\/jats:styled-content>s) occurring on the eyelid and penis. It is presumed that the formation of divided nevi is related with the embryologic development of the eyelid and penis, thus giving a hint about the occurrence time of CMN<\/jats:styled-content> in utero. This article focuses on a formerly undescribed observation of another special clinical appearance of CMN<\/jats:styled-content> discussing possible relation with embryogenesis.<\/jats:p><\/jats:sec>Methods<\/jats:title>The data including photographic documentations of a total number of 86 patients with large CMN<\/jats:styled-content> seen in a single center were reviewed according to the involvement of the nipple and areola by the main mass of the nevus and associated satellite lesions.<\/jats:p><\/jats:sec>Results<\/jats:title>Eight patients presented with CMN<\/jats:styled-content>s involving one (n=6) or both (n=2) breast region. In all of them, CMN<\/jats:styled-content> surrounded the nipple\u2010areola complex without involving these structures. Furthermore, satellite nevi have not been observed on the nipple and areola in any of the 86 patients.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We presume that different developmental time periods of the breast and the nipple\u2013areola complex and the occurrence of the melanocytic lesion before the embryologic development of nipple\u2013areola complex could explain our observation of CMN<\/jats:styled-content> sparing the nipple\u2013areola complex. The term \u201cnipple\u2010sparing nevus of the breast\u201d is suggested for this special clinical appearance of CMN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12610","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T11:29:53Z","timestamp":1430738993000},"page":"514-517","source":"Crossref","is-referenced-by-count":12,"title":["Large Congenital Melanocytic Nevus on the Breast Sparing the Nipple and Areola"],"prefix":"10.1111","volume":"32","author":[{"given":"Can","family":"Baykal","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyhun","family":"Solako\u011flu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alg\u00fcn","family":"Polat Ekinci","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtulu\u015f Didem","family":"Yazgano\u011flu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.06.023"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00577_12.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06811-9.10004-1"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.01.004"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1960.01580020077012"},{"key":"e_1_2_4_7_1","volume-title":"Human embryology and developmental biology","author":"Carlson BM","year":"2009"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.879"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0842"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310007634"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03814.x"},{"key":"e_1_2_4_12_1","volume-title":"The developing human","author":"Moore KL","year":"1998"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12610","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:12:41Z","timestamp":1696025561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/pde.12610"],"URL":"https:\/\/doi.org\/10.1111\/pde.12610","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,4]]}}}