{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T17:49:20Z","timestamp":1723830560263},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Condylomata acuminata (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>), or anogenital warts, are typically benign lesions caused by human papillomavirus infection. Although they are rare, immunocompromised individuals are at a higher risk of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> undergoing transformation into invasive anal squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>). These patients need aggressive evaluation and management. Treatment of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> is challenging, particularly for immunocompromised hosts, in whom warts are resistant to treatment and commonly recur. Currently, there is no gold standard treatment for <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>, especially in children and immunodeficient individuals. We report the case of a 15\u2010year\u2010old immunocompromised girl with severe recalcitrant condyloma that resolved after a course of systemic 5\u2010fluorouracil, mitomycin C, and radiation therapy for <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pde.12617","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T11:41:13Z","timestamp":1430739673000},"source":"Crossref","is-referenced-by-count":2,"title":["Combination Systemic Fluorouracil and Radiation for the Treatment of Recalcitrant Condyloma with Associated Squamous Cell Carcinoma in an Immunocompromised 15\u2010Year\u2010Old Girl"],"prefix":"10.1111","volume":"32","author":[{"given":"Suchismita","family":"Paul","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol E.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Kroshinsky","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.jaad.2010.12.050","article-title":"Human papillomavirus\u2010related genital disease in the immunocompromised host: part I","volume":"66","author":"Gormley RH","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.32-3-115"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02626784"},{"key":"e_1_2_3_5_1","first-page":"119","article-title":"Condyloma acuminata of the rectum with associated malignancy","volume":"63","author":"Burns FJ","year":"1970","journal-title":"Proc R Soc Med"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1971.tb14199.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.12.049"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2011.10.004"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02988993"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03409-5"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.046"},{"issue":"4","key":"e_1_2_3_12_1","first-page":"CD006562","article-title":"5\u2010FU for genital warts in non\u2010immunocompromised individuals","author":"Batista CS","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_3_13_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1001\/archderm.1997.03890370073011","article-title":"Intralesional fluorouracil\/epinephrine injectable gel for treatment of condylomata acuminata. A phase 3 clinical study","volume":"133","author":"Swinehart JM","year":"1997","journal-title":"Arch Dermatol"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12617","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:12:49Z","timestamp":1696025569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,4]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/pde.12617"],"URL":"https:\/\/doi.org\/10.1111\/pde.12617","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,4]]}}}