{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:19:01Z","timestamp":1782285541339,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children with trisomy 21 are prone to developing hematologic disorders, including transient myeloproliferative disorder (<jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>) and acute megakaryoblastic leukemia (<jats:styled-content style=\"fixed-case\">AMKL<\/jats:styled-content>). The papulovesicular eruption of <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content> provides an important clue to the diagnosis. In contrast, <jats:styled-content style=\"fixed-case\">AMKL<\/jats:styled-content> rarely has associated cutaneous findings. We report the case of a 22\u2010month\u2010old child with trisomy 21 who presented with the acute onset of diffusely scattered and crusted papules, plaques, and vesicles. A thorough infectious evaluation was negative and the patient was unresponsive to empiric antibiotic and antiinflammatory therapies. Complete blood count (<jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>) was notable for mild pancytopenia, with a normal peripheral smear. Two weeks later he was reassessed and found to have a population of blasts on repeat <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>. Subsequent evaluation ultimately led to a diagnosis of <jats:styled-content style=\"fixed-case\">AMKL<\/jats:styled-content>. This is the first reported case of a cutaneous eruption in a young child with Down syndrome and transformed <jats:styled-content style=\"fixed-case\">AMKL<\/jats:styled-content>. When children with trisomy 21 present with the acute onset of crusted papules and vesicles that cannot be accounted for by an infectious etiology, a diagnosis of <jats:styled-content style=\"fixed-case\">AMKL<\/jats:styled-content> should be considered even in the absence of a history of <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pde.12643","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T11:39:15Z","timestamp":1437651555000},"source":"Crossref","is-referenced-by-count":2,"title":["Presentation of Acute Megakaryoblastic Leukemia Associated with a <scp>GATA<\/scp>\u20101 Mutation Mimicking the Eruption of Transient Myeloproliferative Disorder"],"prefix":"10.1111","volume":"32","author":[{"given":"Markus D.","family":"Boos","sequence":"first","affiliation":[{"name":"Section\u00a0of Dermatology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia Pennsylvania"},{"name":"Department of Dermatology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Wine Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of South Carolina Charleston South Carolina"},{"name":"Department of Pediatrics Medical University of South Carolina Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Division of Oncology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto A.","family":"Novoa","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford Medical Center Palo Alto California"},{"name":"Department of Dermatology Stanford Medical Center Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Y.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa J.","family":"Perman","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Department of Pediatrics Children's Hospital of Philadelphia Philadelphia Pennsylvania"},{"name":"Department of Dermatology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.07.011"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12041"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevOncog.v16.i1-2.40"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2448"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05501.x"},{"key":"e_1_2_3_7_1","first-page":"760","article-title":"Vesiculopustular eruptions in Down syndrome neonates with myeloproliferative disorders","volume":"137","author":"Nijhawan A","year":"2001","journal-title":"Arch 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