{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T19:10:32Z","timestamp":1760987432936},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Beta\u2010blockers have become the treatment of choice for problematic infantile hemangiomas (<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s). Nadolol, a nonselective beta\u2010blocker with potential dosing advantages and a better safety profile than that of other beta\u2010blockers, has been studied as an alternative therapeutic option. Our objective was to characterize the efficacy and safety of oral nadolol in the treatment of proliferating <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted at the Hospital for Sick Children between February 2010 and April 2012 in patients treated with nadolol for proliferating <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s causing functional impairment or cosmetic disfigurement. The primary outcome was the percentage involution measured independently by two assessors who scored changes in the extent of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s by comparing serial photographs using a 100\u2010mm visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>), on which 5\u00a0mm represented 10% change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four patients treated with nadolol for <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s with adequate photographic documentation were identified. The median age at presentation was 4.5\u00a0months (interquartile range 1.5\u20137.9\u00a0mos). There was a mean improvement of 91.8\u00a0\u00b1\u00a011.1%. At least 50% improvement was noted in 42 (95%) patients and 75% improvement in 39 (89%) patients. The mean time to 50% and 75% improvement was 2.9 and 3.7\u00a0months, respectively. Analysis of variance showed that younger age at the time of treatment start was associated with a higher mean <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score (% involution) (p\u00a0&lt;\u00a00.05). Treatment duration (mean 9.5\u00a0\u00b1\u00a05.6\u00a0months) had no significant effect on <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score. Test of interobserver correlation showed good agreement (intraclass correlation coefficient\u00a0=\u00a00.86, p\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral nadolol is efficacious in patients with problematic <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s. Further large\u2010scale prospective comparative studies are warranted to compare nadolol with other beta\u2010blockers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12655","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T08:21:32Z","timestamp":1437985292000},"page":"690-695","source":"Crossref","is-referenced-by-count":10,"title":["Oral Nadolol for the Treatment of Infantile Hemangiomas: A Single\u2010Institution Retrospective Cohort Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Harkamal Kaur","family":"Randhawa","sequence":"first","affiliation":[{"name":"Section\u00a0of Dermatology Hospital for Sick Children University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathryn","family":"Sibbald","sequence":"additional","affiliation":[{"name":"Section\u00a0of Dermatology Hospital for Sick Children University of Toronto Toronto Ontario 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