{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T08:40:25Z","timestamp":1707381625214},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonbullous erythema multiforme (<jats:styled-content style=\"fixed-case\">NBEM<\/jats:styled-content>) is an acute, immune\u2010mediated, self\u2010limiting skin disease with distinctive target lesions. Its pathogenesis is unclear, but most cases are considered to be infection related or drug related. In adults, the main precipitating factor is infection. This study reviewed a 10\u2010year experience with hospitalized children with <jats:styled-content style=\"fixed-case\">NBEM<\/jats:styled-content> in a tertiary pediatric medical center in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>srael with a focus on precipitating factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical files of all children hospitalized from 2001 to 2011 with the diagnosis of <jats:styled-content style=\"fixed-case\">NBEM<\/jats:styled-content> were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010seven patients (55 boys and 42 girls) met the inclusion criteria. The mean age was 4.0\u00a0years. At least one precipitating factor was recognized in 72 cases; the remainders were classified as idiopathic. The most common factor was drugs (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>45), particularly penicillin (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>30), followed by infection with various pathogens (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>27) including <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>pstein\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arr virus (7), group <jats:styled-content style=\"fixed-case\">A <\/jats:styled-content><jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>treptococcus<\/jats:italic> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>6), <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycoplasma pneumoniae<\/jats:italic> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>5) and herpes simplex virus (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4). Analysis according to age showed that medication was the most common precipitating factor in the first year of life, and infection was as common as drugs in the older age groups (1\u201318\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unlike adult <jats:styled-content style=\"fixed-case\">NBEM<\/jats:styled-content>, the majority of pediatric <jats:styled-content style=\"fixed-case\">NBEM<\/jats:styled-content> is associated with medications, especially penicillin. This may be due to the frequent use of antibiotics in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12659","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T05:46:09Z","timestamp":1438235169000},"page":"701-703","source":"Crossref","is-referenced-by-count":8,"title":["Nonbullous Erythema Multiforme in Hospitalized Children: A 10\u2010Year Survey"],"prefix":"10.1111","volume":"32","author":[{"given":"Noy","family":"Keller","sequence":"first","affiliation":[{"name":"Department of Pediatrics B Schneider Children's Medical Center of Israel Petach Tikva and Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oded","family":"Gilad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics B Schneider Children's Medical Center of Israel Petach Tikva and Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphna","family":"Marom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics B Schneider Children's Medical Center of Israel Petach Tikva and Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nufar","family":"Marcus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics B Schneider Children's Medical Center of Israel Petach Tikva and Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben Zion","family":"Garty","sequence":"additional","affiliation":[{"name":"Department of Pediatrics B Schneider Children's Medical Center of Israel Petach Tikva and Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051244"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)34430-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05348.x"},{"key":"e_1_2_5_5_1","volume-title":"On diseases of the skin including the exanthemata (translated by CH Fagge)","author":"Hebra F","year":"1866"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.8.1019"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12484029"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.83.4.347"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)80003-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198205000-00005"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200225130-00006"},{"key":"e_1_2_5_13_1","first-page":"283","article-title":"Erythema multiforme: a review of twenty cases","volume":"26","author":"Martin MM","year":"1998","journal-title":"Allergol Immunopathol (Madr)"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)80090-0"},{"key":"e_1_2_5_15_1","first-page":"319","volume-title":"Dermatology","author":"French LE","year":"2012"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12659","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T11:14:00Z","timestamp":1696158840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,30]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/pde.12659"],"URL":"https:\/\/doi.org\/10.1111\/pde.12659","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,30]]}}}