{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:51:06Z","timestamp":1792165866295,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Colonization with <jats:italic>Staphylococcal aureus<\/jats:italic> is markedly more frequent in individuals with atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) than in unaffected individuals. Chronic scratching leads to worsening of an existing defect in the epidermal barrier, which can allow <jats:italic>S.\u00a0aureus<\/jats:italic> invasion into the bloodstream and subsequent systemic infections. We report two unusual cases of systemic illness in individuals with AD. One developed infective endocarditis followed by a stroke and the other developed septic arthritis and osteomyelitis. We performed an extensive literature review of reported systemic complications caused by <jats:italic>S.\u00a0aureus<\/jats:italic> in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Although reports are rare, practitioners should be aware of these important, albeit unlikely, complications of staphylococcal superinfections in individuals with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/pde.12665","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T06:50:09Z","timestamp":1441349409000},"page":"792-796","source":"Crossref","is-referenced-by-count":48,"title":["Serious Complications from <i>Staphylococcal aureus<\/i> in Atopic Dermatitis"],"prefix":"10.1111","volume":"32","author":[{"given":"Devika","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Children's Hospital of Michigan Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marla N.","family":"Jahnke","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Children's Hospital of Michigan Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00686.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.11.027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02980.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.022"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01725.x"},{"key":"e_1_2_8_7_1","first-page":"267","article-title":"A tragic case of atopic eczema: malnutrition and infections despite multivitamins and supplements","volume":"11","author":"Hon KL","year":"2012","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"e_1_2_8_8_1","first-page":"S29","article-title":"Recurrent deep\u2010seated Staphylococcal aureus infections of unclear etiology","volume":"31","author":"Carr T","year":"2011","journal-title":"J Clin Immunol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890250037007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1997.tb00688.x"},{"key":"e_1_2_8_11_1","first-page":"135","article-title":"Infective endocarditis with a huge mitral vegetation related to atopic dermatitis and high serum level of infection\u2010related antiphospholipid antibody","volume":"42","author":"Harada M","year":"2003","journal-title":"J Cardiol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.03.040"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6207"},{"key":"e_1_2_8_14_1","first-page":"239","article-title":"Guess what! 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