{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:23:33Z","timestamp":1774715013299,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Propranolol has become the first\u2010line treatment for complicated infantile hemangiomas (CIH<\/jats:styled-content>s) worldwide. Recommendations for monitoring infants undergoing propranolol therapy vary. Data on long\u2010term blood pressure (BP<\/jats:styled-content>) monitoring have not been reported before.<\/jats:p><\/jats:sec>Objective<\/jats:title>The objective of the current study was to monitor BP<\/jats:styled-content> in full\u2010term infants during the induction and maintenance phase of propranolol therapy.<\/jats:p><\/jats:sec>Methods<\/jats:title>BP<\/jats:styled-content> was monitored prospectively in 109 infants (mean age 2.8\u00a0mos, range 1\u20135\u00a0mos) with CIH<\/jats:styled-content>s during the induction (3\u20134\u00a0days in the hospital during up\u2010dosing from 0.5 to 2.0\u00a0mg\/kg\/day) and maintenance (6\u00a0mos) phases of oral propranolol therapy.<\/jats:p><\/jats:sec>Results<\/jats:title>Four children were excluded from the study because of sinus bradycardia (n<\/jats:italic>\u00a0=\u00a02 [1.8%]) or lethargy (n<\/jats:italic>\u00a0=\u00a02 [1.8%]). Mean systolic BP<\/jats:styled-content> (SBP<\/jats:styled-content>) decreased by 5\u00a0mmHg with the increase in propranolol dosage. Low (<5th percentile) SBP<\/jats:styled-content> or diastolic BP<\/jats:styled-content> (DBP<\/jats:styled-content>) was observed in 2 of 105 children (1.9%) each. During the maintenance phase, 2 of 105 children (1.9%) had occasional SBP<\/jats:styled-content> readings of less than 70\u00a0mmHg. No hypotension was observed after the third month of therapy. Low DBP<\/jats:styled-content> (<36\u00a0mmHg) was recorded in 16 (15.2%) children after the first month, in 8.6% after the second, and in 2.9% during the third and fourth months of therapy. No patients exhibited clinical hypotension, bradycardia, or other known side effects of propranolol. Clinical response to therapy was excellent.<\/jats:p><\/jats:sec>Limitations<\/jats:title>Reference BP<\/jats:styled-content> values were derived from published tables, not from an untreated control group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In healthy full\u2010term infants, propranolol (2\u00a0mg\/kg\/day divided in three doses) is well tolerated. No clinically significant hypotension was observed. We conclude that for otherwise healthy infants, BP<\/jats:styled-content> monitoring during long\u2010term propranolol therapy for CIH<\/jats:styled-content>s is not necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12681","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T09:46:48Z","timestamp":1442915208000},"page":"802-807","source":"Crossref","is-referenced-by-count":18,"title":["Blood Pressure Monitoring During the Induction and Maintenance Period of Propranolol Therapy for Complicated Infantile Hemangiomas: A Prospective Study of 109 Infants"],"prefix":"10.1111","volume":"32","author":[{"given":"Meike","family":"Hengst","sequence":"first","affiliation":[{"name":"Department of Pediatrics Catholic Children's Hospital Wilhelmstift Hamburg Germany"},{"name":"Department of Pediatric Dermatology Catholic Children's Hospital Wilhelmstift Hamburg 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