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In both cases, intracranial vascular anomalies and hemangiomas were found incidentally during evaluation of unilateral proptosis. Neither infant had evidence of cutaneous segmental <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> of the face or neck, which might have provided a clue to the diagnosis of <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome or of intracranial hemangiomas. In one case, intracranial involvement was particularly extensive and function threatening, with mass effect on the brain parenchyma. These cases serve to highlight the fact that clinical findings of proptosis, globe deviation, and strabismus should prompt immediate imaging to confirm the presence of orbital <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s and to exclude other diagnoses. Moreover, based on our cases and the embryologic origin of the orbit as a unique developmental unit, patients with confirmed retro\u2010orbital <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s should undergo evaluation for anomalies associated with <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome. Patients with orbital <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s and an additional major criterion for <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome should be considered to have definite, and not just possible, <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome.<\/jats:p>","DOI":"10.1111\/pde.12695","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T09:10:44Z","timestamp":1444295444000},"source":"Crossref","is-referenced-by-count":15,"title":["Orbital Hemangioma with Intracranial Vascular Anomalies and Hemangiomas: A New Presentation of <scp>PHACE<\/scp> Syndrome?"],"prefix":"10.1111","volume":"32","author":[{"given":"Nina K.","family":"Antonov","sequence":"first","affiliation":[{"name":"Transitional Year Program Memorial Sloan\u2010Kettering Cancer Center New York New 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