{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:59:54Z","timestamp":1780646394489,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transepidermal water loss (<jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>) is the normal, constitutive loss of water vapor from the skin in the absence of sweat gland activity. It is regarded as one of the most important parameters for characterizing skin barrier function, and the values are dependent on multiple variables. The objective of this study was to evaluate <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> in neonates using a closed\u2010 chamber system, and determine if there is a variation of <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> with the mode of delivery, pre\u2010term birth, low birthweight or phototherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study was conducted in 104 healthy neonates, 30 neonates in the Neonatal Intensive Care Unit (<jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content>) and 40 adults using a noninvasive, closed\u2010 chamber system (VapoMeter<jats:sup>\u2122<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant difference in <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> was noted between newborns and adults. No remarkable difference in <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> was seen between boys or men and girls or women or those born via normal vaginal birth and caesarean section, but <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> was significantly higher in preterm and low birthweight neonates. Significantly higher <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> was noted from the antecubital fossa of the neonates who received phototherapy when compared with six other sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The closed\u2010 chamber system is an acceptable alternative to the more widely used open\u2010chamber system. The higher mean <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> in neonates suggests that the epidermal barrier is still adapting to extrauterine life, making newborn skin more sensitive and requiring appropriate, age adapted care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12704","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T09:10:39Z","timestamp":1444295439000},"page":"33-37","source":"Crossref","is-referenced-by-count":19,"title":["Transepidermal Water Loss in Neonates: Baseline Values Using a Closed\u2010Chamber System"],"prefix":"10.1111","volume":"33","author":[{"given":"Teena R.","family":"Mathanda","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Venereology, and Leprosy Father Muller Medical College Hospital Kankanady Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"M. Bhat","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology, and Leprosy Father Muller Medical College Hospital Kankanady Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Hegde","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Father Muller Medical College Hospital Kankanady Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivaraja","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Father Muller Medical College Hospital Kankanady Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015941412620"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12106"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1152\/ajplegacy.1942.137.3.492","article-title":"Evaporation from human skin with sweat glands inactivated","volume":"187","author":"Pinson EA","year":"1942","journal-title":"Am J Physiol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.66575"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10068.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12274"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10659.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.11.858"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.1.105"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00437.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2003.00025.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05257.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.11.013"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2000.0013"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000242513"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211107"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701239"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12704","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T06:05:17Z","timestamp":1695708317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/pde.12704"],"URL":"https:\/\/doi.org\/10.1111\/pde.12704","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,8]]}}}