{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:03:18Z","timestamp":1770886998156,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mayo Clinic Department of Dermatology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> Penile and scrotal swelling can occur as an extraintestinal manifestation of Crohn's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) and is thought to be an uncommon form of metastatic <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>). Because of the rarity of this manifestation, much is unknown concerning the presentation, treatment, and response to therapy in children with genital <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>. <jats:bold>Methods:<\/jats:bold> Boys ages 1 to 17 years presenting with genital edema and a confirmed diagnosis or strong suspicion of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> who were evaluated at the Mayo Clinic between 1996 and 2014 were included for review. We sought to characterize the clinical and pathologic features of genital <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> and response to treatment in our cohort of patients. <jats:bold>Results:<\/jats:bold> Eight patients with genital <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content> were identified from our institution (mean age 11.4 yrs, range 7\u201316yrs). Seven (88%) patients experienced cutaneous symptoms before a formal diagnosis of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> was made, and two of the seven had no adverse gastrointestinal symptoms at that time. Patients were prescribed an average of 3.4 medications (topical and systemic) for management of their gastrointestinal <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>. <jats:bold>Conclusions:<\/jats:bold> Penile and scrotal swelling can occur as an extraintestinal manifestation of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and is thought to be an uncommon form of <jats:styled-content style=\"fixed-case\">MCD<\/jats:styled-content>. In boys, genital swelling typically precedes intestinal <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. Treatment of the underlying <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> with systemic medications was most helpful in this series. An evaluation for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> is necessary in all patients presenting with unexplained genital swelling.<\/jats:p>","DOI":"10.1111\/pde.12772","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T11:03:48Z","timestamp":1452769428000},"page":"172-177","source":"Crossref","is-referenced-by-count":19,"title":["Penile and Scrotal Swelling: An Underrecognized Presentation of Crohn's Disease"],"prefix":"10.1111","volume":"33","author":[{"given":"Benjamin J.","family":"Barrick","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha M.","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"},{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Schoch","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian T.","family":"McEvoy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"},{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Hand","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"},{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester Minnesota"},{"name":"Department of Medical Genetics Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carilyn N.","family":"Wieland","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"},{"name":"Division of Anatomic Pathology Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn M. R.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"},{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01705.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.11.029"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028008419.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00991.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1829"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.081"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80320-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2009.08.010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64561-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6112.552"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.06.033"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.380"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12772","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:01:52Z","timestamp":1695538912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,14]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/pde.12772"],"URL":"https:\/\/doi.org\/10.1111\/pde.12772","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,14]]}}}