{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:19:17Z","timestamp":1759814357468},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>In addition to several infectious and neoplastic cutaneous entities, plasmacytoid dendritic cells (<jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>s) have been shown to be involved in the pathogenesis of multiple cutaneous inflammatory and autoimmune disorders, including those characterized histologically by an \u201cinterface dermatitis\u201d pattern such as lupus or lichen planus (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>), but their role in lichen striatus (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>), which is also known to have this histologic inflammatory pattern, has never been studied. The objective of the study was to investigate the role of <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>s in LS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> patients were found in our database and were immunohistochemically tested for <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content> occurrence and activity using anti\u2010blood\u2010derived dendritic cell antigen\u20102 and anti\u2010myxovirus resistance protein A (MxA) antibodies, respectively. These individuals were also compared with 15 individuals with <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>s were present in all individuals with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>, but they were less abundant in those with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>, although MxA (surrogate marker of local type I interferon production and thus an indirect assessment of <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content> activity) was similarly intense and diffuse in all individuals with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>. In addition to being part of the upper dermal inflammatory bandlike infiltrate as in <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LS<\/jats:styled-content> cases, unlike <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>, also showed perieccrine <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content>s constitute a central component of the inflammatory infiltrate in <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>, suggesting a significant role in its pathogenesis. <jats:styled-content style=\"fixed-case\">pDC<\/jats:styled-content> distribution (perieccrine distribution) could also help in microscopically differentiating <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12824","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T03:40:43Z","timestamp":1456976443000},"page":"301-306","source":"Crossref","is-referenced-by-count":8,"title":["Plasmacytoid Dendritic Cells and Type I Interferon Signature in Lichen Striatus"],"prefix":"10.1111","volume":"33","author":[{"given":"Dana","family":"Badr","sequence":"first","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Abadi","sequence":"additional","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazen","family":"Kurban","sequence":"additional","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ossama","family":"Abbas","sequence":"additional","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1995.tb00734.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.280202.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21302.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21403.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2012.01844.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01691.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.110780"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1993.tb02211.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.0816"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181bb6bc2"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9278-8"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0411190"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.12.1823"},{"key":"e_1_2_5_15_1","first-page":"98","article-title":"CD123 (interleukin 3 receptor alpha chain)","volume":"15","author":"Moretti S","year":"2001","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.830"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.02.007"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431174"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01475.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12932"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700052"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00527.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2009.06.013"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61689-6"},{"key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1001\/archderm.1993.01680310094017","article-title":"Interface dermatitis. 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