{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:59:04Z","timestamp":1790499544739,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to better understand the pathogenesis, clinical features, prognosis, and treatment of neonatal autoimmune blistering diseases (<jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>s). We searched Medline, Embase, PubMed, Latin American and Caribbean Health Sciences Literature, and reference lists of identified articles. Inclusion criteria were articles published from 1946 to December 2014 in any language. Exclusion criteria were age greater than 4 weeks and no confirmed <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content> diagnosis. We identified 51 cases of neonatal <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>s: 34 cases of pemphigus (31 pemphigus vulgaris [<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>], 3 pemphigus foliaceus [<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>]) and 17 cases of pemphigoid diseases (9 bullous pemphigoid [<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>], 5 linear immunoglobulin A bullous dermatosis [<jats:styled-content style=\"fixed-case\">LABD<\/jats:styled-content>], 1 <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LABD<\/jats:styled-content>, 1 epidermolysis bullosa acquisita, 1 bullous systemic lupus erythematosus). Pemphigoid diseases had a higher male predominance (male:female ratio 4.6:1) than pemphigus (male:female ratio 1:1.06) (p = 0.004). Pemphigus had a higher proportion presenting at birth (79.4%) than pemphigoid diseases (29.4%) (p = 0.008). The most common sites involved were the trunk (63.0%), followed by the head and neck (60.9%). The mucosal membranes were involved in 32.6% of cases (27.6% in pemphigus, 41.6% in pemphigoid diseases). Only 33.3% used systemic therapy, and 75.5% achieved control within 3 weeks. Most <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> cases, but not <jats:styled-content style=\"fixed-case\">LABD<\/jats:styled-content>s, reported maternal disease. In pemphigus cases, 75.0% of mothers had active disease and 25.0% were in control. Pregnant women with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> of any severity can passively transfer autoantibodies leading to neonatal <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>. Pemphigoid diseases are more likely to present after birth and may be more male predominant. The presentation of <jats:styled-content style=\"fixed-case\">LABD<\/jats:styled-content>s may be different from that of all other <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/pde.12859","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T07:39:39Z","timestamp":1460965179000},"page":"367-374","source":"Crossref","is-referenced-by-count":50,"title":["Neonatal Autoimmune Blistering Disease: A Systematic Review"],"prefix":"10.1111","volume":"33","author":[{"given":"Cathy Y.","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology St. George Hospital Sydney New South Wales Australia"},{"name":"Department of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Zhen","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology St. George Hospital Sydney New South Wales Australia"},{"name":"Department of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dedee F.","family":"Murrell","sequence":"additional","affiliation":[{"name":"Department of Dermatology St. George Hospital Sydney New South Wales Australia"},{"name":"Department of Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66829-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"e_1_2_6_4_1","first-page":"169","article-title":"A congenital acantholytic bullous eruption in the newborn infant of a pemphigous mother","volume":"12","author":"Ruocco YRA","year":"1975","journal-title":"Ital Gen Rev Dermatol"},{"key":"e_1_2_6_5_1","first-page":"59","article-title":"A case of bullous dermatosis at the end of pregnancy transmitted to the newborn infant: herpes gestationis","volume":"79","author":"Koslowski JP","year":"1984","journal-title":"Rev Fr Gynecol Obstet"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1001\/archderm.1979.04010030024009","article-title":"In vivo bound pemphigus antibodies in a stillborn infant. 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