{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:55:12Z","timestamp":1783335312317,"version":"3.54.6"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T00:00:00Z","timestamp":1460505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Focal epithelial hyperplasia (<jats:styled-content style=\"fixed-case\">FEH<\/jats:styled-content>), or Heck's disease, is an uncommon benign proliferation of oral mucosa caused by the human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>), particularly subtypes 13 and 32. The disease typically presents in young Native American patients and is characterized by multiple asymptomatic papules and nodules on the oral mucosa, lips, tongue, and gingiva. The factors that determine susceptibility to <jats:styled-content style=\"fixed-case\">FEH<\/jats:styled-content> are unknown, but the ethnic and geographic distribution of <jats:styled-content style=\"fixed-case\">FEH<\/jats:styled-content> suggests that genetic predisposition, particularly having the human lymphocytic antigen <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>4 type, may be involved in pathogenesis. We report a case of <jats:styled-content style=\"fixed-case\">FEH<\/jats:styled-content> with polymerase chain reaction detection of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>13 in a healthy 11\u2010year\u2010old Hispanic girl and discuss the current understanding of disease pathogenesis, susceptibility, and treatment.<\/jats:p>","DOI":"10.1111\/pde.12862","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T09:04:45Z","timestamp":1460538285000},"source":"Crossref","is-referenced-by-count":13,"title":["Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13"],"prefix":"10.1111","volume":"33","author":[{"given":"Mary A.","family":"Brehm","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miahil","family":"Firan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas"},{"name":"Department of Pathology Children's Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rady","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Studies in Mucocutaneous Diseases Department of Dermatology Medical School University of Texas at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nnenna","family":"Agim","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(65)90192-1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12538"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(99)00180-9"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.10.1227"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00830.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12862","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:20:26Z","timestamp":1695514826000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,13]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/pde.12862"],"URL":"https:\/\/doi.org\/10.1111\/pde.12862","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,13]]}}}