{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:41:20Z","timestamp":1790700080691,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Meda Pharma"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is often the first step in the atopic march leading to the development of asthma or allergic rhinitis. The goal of this study was to determine whether early intervention with pimecrolimus limits the atopic march in infants with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and to evaluate its efficacy and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a 3\u2010year double\u2010blind study in which patients were randomized to pimecrolimus or vehicle and then open\u2010label pimecrolimus for a planned further 3 years. Rescue topical corticosteroid was permitted if 3 days of study medication led to no improvement; investigators made decisions on rescue medication until week 14 and caregivers thereafter. Efficacy assessments included disease\u2010free days, Eczema Area and Severity Index, and body surface area affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Infants ages 3 to 18 months with recent\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (\u22643 months) were observed for a mean of 2.8 years (<jats:italic>N<\/jats:italic> = 1,091). No significant differences between pimecrolimus\u2010 and placebo\u2010treated groups were found in the percentage of patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> who developed asthma (10.7%) or other allergic conditions (allergic rhinitis, 22.4%; food allergy, 15.9%; allergic conjunctivitis, 14.1%; one or more atopic comorbidities, 37.0%) by study end. Allergic rhinitis, food allergy, and having one or more atopic comorbidities (but not asthma or allergic conjunctivitis alone) developed significantly more often in infants with greater <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> severity at baseline. Pimecrolimus was significantly more effective than vehicle for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> treatment at week 14. Adverse event incidences were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This longitudinal observation of infants with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> provides evidence of the atopic march. Pimecrolimus was safe and effective in infants with mild to moderate <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12867","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T08:46:47Z","timestamp":1465289207000},"page":"388-398","source":"Crossref","is-referenced-by-count":130,"title":["Study of the Atopic March: Development of Atopic Comorbidities"],"prefix":"10.1111","volume":"33","author":[{"given":"Lynda","family":"Schneider","sequence":"first","affiliation":[{"name":"Boston Children's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Hanifin","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Boguniewicz","sequence":"additional","affiliation":[{"name":"National Jewish Health University of Colorado Denver Colorado"},{"name":"School of Medicine University of Colorado Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence F.","family":"Eichenfield","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Spergel","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Children's Hospital of Philadelphia and Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rada","family":"Dakovic","sequence":"additional","affiliation":[{"name":"Meda Pharma GmbH &amp; Co. KG Bad Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Paller","sequence":"additional","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital of Chicago and Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.251"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.10.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap2007.28.3048"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1188"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1990"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126500"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.65"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.08.015"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.09.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02539-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.120015"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1998.tb00356.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2006.00062.x"},{"key":"e_1_2_7_15_1","volume-title":"Pediatric Allergy\u2014Principles and Practice","author":"Leung DYM","year":"2003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(81)90001-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780030302"},{"key":"e_1_2_7_18_1","volume-title":"Categorical Data Analysis Using the SAS System","author":"Stokes ME","year":"2000"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.05.042"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.041"},{"key":"e_1_2_7_21_1","first-page":"202","article-title":"The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma","volume":"5","author":"Bantz SK","year":"2014","journal-title":"J Clin Cell Immunol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.033"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12867","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T15:43:47Z","timestamp":1695743027000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/pde.12867"],"URL":"https:\/\/doi.org\/10.1111\/pde.12867","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,7]]}}}