{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:40:46Z","timestamp":1778290846566,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the development and clinical characteristics of nail changes in hand, foot, and mouth disease (<jats:styled-content style=\"fixed-case\">HFMD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A telephone survey was conducted with the parents of patients diagnosed with <jats:styled-content style=\"fixed-case\">HFMD<\/jats:styled-content> in the Fourth General Hospital of Nanhai from June to August 2013 to document nail changes within 3\u00a0months of diagnosis of <jats:styled-content style=\"fixed-case\">HFMD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Valid survey results were obtained from 273 cases. Definitive nail changes were identified in 56 patients (20.5%). More boys (25.8%) than girls (10.6%) (p\u00a0&lt;\u00a00.01) showed changes. The age distribution ranged from 1 to 5\u00a0years, and nail changes were rare in children younger than 1\u00a0year of age (p\u00a0&lt;\u00a00.01). Nail changes were usually seen 1 to 2\u00a0months after the onset of <jats:styled-content style=\"fixed-case\">HFMD<\/jats:styled-content> and lasted for 1 to 8\u00a0weeks, most for approximately 4\u00a0weeks. Toenails or fingernails could be affected and the changes were more likely to occur synchronously. Fingernails were more commonly involved than toenails. When both fingernails and toenails were involved, this typically occurred synchronously. Although there were cases with all toenails and fingernails involved (16.1%), we did not encounter any instances involving 13 to 19 nails. The nail changes mainly presented as onychomadesis. Spontaneous recovery without special treatment was the course for all patients. No relapse or new nail involvement was identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nail change associated with <jats:styled-content style=\"fixed-case\">HFMD<\/jats:styled-content> usually occurs within 1 to 2\u00a0months after onset, mainly presents as onychomadesis, and is a self\u2010limited process. Possible mechanisms are discussed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12878","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T08:12:47Z","timestamp":1465805567000},"page":"424-428","source":"Crossref","is-referenced-by-count":13,"title":["Late\u2010Onset Nail Changes Associated with Hand, Foot, and Mouth Disease: A Clinical Analysis of 56 Cases"],"prefix":"10.1111","volume":"33","author":[{"given":"Dong\u2010ling","family":"Long","sequence":"first","affiliation":[{"name":"Department of Dermatology Fourth General Hospital of Nanhai Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010yuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fourth General Hospital of Nanhai Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai\u2010zi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Public Health Fourth General Hospital of Nanhai Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui\u2010yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Public Health Fourth General Hospital of Nanhai Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan\u2010tao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Public Health Fourth General Hospital of Nanhai Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01702.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"pii: 19663","DOI":"10.2807\/ese.15.37.19663-en","article-title":"Onychomadesis outbreak linked to hand, foot, and mouth disease, Spain, July 2008","volume":"15","author":"Guimbao J","year":"2010","journal-title":"Euro Surveill"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05287.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310100815"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-346"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2014.26.2.280"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090438"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2009.07.033"},{"key":"e_1_2_6_10_1","volume-title":"A Guide to Clinical Management and Public Health Response for Hand, Foot and Mouth Disease (HFMD)","author":"World Health Organization","year":"2011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01161.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1712.110395"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01004-14"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12878","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T15:43:41Z","timestamp":1695743021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,13]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/pde.12878"],"URL":"https:\/\/doi.org\/10.1111\/pde.12878","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,13]]}}}