{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:45:43Z","timestamp":1756385143288},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether Gianotti\u2013Crosti syndrome (<jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content>) in children is associated with atopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The setting was two outpatient clinic. Diagnoses of asthma and atopic dermatitis (AD) were made according to internationally accepted diagnostic criteria. Allergic rhinitis, atopic urticaria, and allergic conjunctivitis were diagnosed clinically. Participants were children with <jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content> diagnosed over the previous 5 years. For any child with <jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content>, we extracted the record of the subsequent age and sex pair\u2010matched child seen for problems unrelated to the skin as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We retrieved the records of 37 pairs of study and control subjects; 28 (76%) children with <jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content> and 9 (24%) controls had AD (risk ratio [<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>] = 3.11[95% confidence interval {<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>} 1.73, 5.73]), 31 (84%) children with <jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content> and 19 (51%) controls had at least one atopic condition (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> = 1.63 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.13, 2.18]) and 11 (30%) children with <jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content> and 2 (5%) controls had at least three atopic conditions (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> = 5.50 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.29, 35.35]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content> is significantly associated with AD and the presence of atopic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12886","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T22:27:59Z","timestamp":1466893679000},"page":"488-492","source":"Crossref","is-referenced-by-count":11,"title":["Is Gianotti\u2013Crosti Syndrome Associated with Atopy? A Case\u2013Control Study and a Postulation on the Intrinsic Host Factors in Gianotti\u2013Crosti Syndrome"],"prefix":"10.1111","volume":"33","author":[{"given":"Antonio","family":"Chuh","sequence":"first","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care Chinese University of Hong Kong and Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Zawar","sequence":"additional","affiliation":[{"name":"Skin Diseases Center Nashik India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Lee","sequence":"additional","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care Chinese University of Hong Kong and Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Sciallis","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"171","article-title":"Viral anicteric hepatitis in infantile papular acrodermatitis","volume":"12","author":"Gianotti F","year":"1966","journal-title":"Epatologia"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92786-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)93087-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)31866-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/138.2.211"},{"key":"e_1_2_6_7_1","first-page":"407","article-title":"Detection of hepatitis B surface antigen subtype adr in an epidemic of papular acrodermatitis of childhood (Gianotti's disease)","volume":"35","author":"Kanzaki S","year":"1981","journal-title":"Acta Med Okayama"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2739\/kurumemedj.35.147"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1001\/archderm.1984.01650430077014","article-title":"Gianotti\u2010Crosti syndrome. 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