{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:31:04Z","timestamp":1792189864223,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Erythema annulare centrifugum (<jats:styled-content style=\"fixed-case\">EAC<\/jats:styled-content>) is an uncommon eruption that may be a hypersensitivity reaction. Treatment of <jats:styled-content style=\"fixed-case\">EAC<\/jats:styled-content> is best accomplished by eliminating the underlying cause. Although many triggers have been reported, the inciting factor is unknown in most patients. We hypothesized that occult yeast overgrowth may trigger <jats:styled-content style=\"fixed-case\">EAC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">EAC<\/jats:styled-content> of unknown etiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five children with <jats:styled-content style=\"fixed-case\">EAC<\/jats:styled-content> were treated empirically with oral fluconazole. These cases were retrospectively reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Improvement was noted in all patients; three cleared entirely. Two patients experienced recurrences after successful treatment, which were treated with a second course of fluconazole. The treatment was well tolerated, without adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral fluconazole was an effective treatment in five children with EAC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12909","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T19:57:37Z","timestamp":1466884657000},"page":"501-506","source":"Crossref","is-referenced-by-count":9,"title":["Pediatric Erythema Annulare Centrifugum Treated with Oral Fluconazole: A Retrospective Series"],"prefix":"10.1111","volume":"33","author":[{"given":"Lacey L.","family":"Kruse","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Feinberg School of Medicine Northwestern University Chicago Illinois"},{"name":"Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi M.","family":"Kenner\u2010Bell","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Feinberg School of Medicine Northwestern University Chicago Illinois"},{"name":"Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Pediatrics Feinberg School of Medicine Northwestern University Chicago Illinois"},{"name":"Ann &amp; Robert H. 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