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These deficiencies cause excessive metabolites to accumulate in multiple organs. There are eight different<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>disorders, contributing to the wide variation in clinical presentation. Depending on the severity and subtype of the disease, some children live normal life spans, while others have a more grim prognosis. Children with<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>can present with neurologic, behavioral, skeletal, cardiovascular, gastrointestinal, or respiratory abnormalities. Cutaneous manifestations are mostly nonspecific and can include coarse facial features, thickened skin, and excessive hair growth. More specific skin findings include ivory\u2010colored \u201cpebbly\u201d papules found in Hunter syndrome and extensive dermal melanocytosis found in Hurler and Hunter syndromes. Early diagnosis of<jats:styled-content style=\"fixed-case\">MPS<\/jats:styled-content>disorders is extremely important to minimize the progression of the disease and for early initiation of appropriate treatment.<\/jats:p>","DOI":"10.1111\/pde.12971","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T10:15:40Z","timestamp":1473243340000},"page":"594-601","source":"Crossref","is-referenced-by-count":19,"title":["Cutaneous Manifestations of Mucopolysaccharidoses"],"prefix":"10.1111","volume":"33","author":[{"given":"Mimi C.","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of British Columbia Vancouver BC 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