{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T14:51:38Z","timestamp":1784472698059,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Pyoderma gangrenosum (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>) is a neutrophilic dermatosis rarely seen in children. Its features have not been well characterized in children. We sought to characterize the clinical features, etiologic associations, and treatment of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> in children younger than 18 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of children younger than 18 years with <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> at the Mayo Clinic from January 1976 to August 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen children with <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> were identified (<jats:italic>n<\/jats:italic> = 8; 62% female). All had ulcerations, with 62% having pustular lesions. Sites of involvement included the trunk (77%), lower extremities (77%), upper extremities (38%), and head and neck (38%). Nine (69%) had an underlying comorbidity, including seven with Crohn's disease (54%), one with juvenile idiopathic arthritis (8%), and one with pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (8%). Treatments included topical or local care (92%) and systemic therapies (85%) such as oral corticosteroids (62%) and sulfasalazine or related 5\u2010aminosalicylate drugs (46%). The clinical course did not correlate with that of the underlying systemic disease and response to treatment varied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pediatric <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> has a more varied anatomic distribution and a greater predominance of pustular lesions than <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> in adults and a strong association with inflammatory bowel disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12990","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T15:17:21Z","timestamp":1476285441000},"page":"39-45","source":"Crossref","is-referenced-by-count":42,"title":["Pediatric Pyoderma Gangrenosum: A Retrospective Review of Clinical Features, Etiologic Associations, and Treatment"],"prefix":"10.1111","volume":"34","author":[{"given":"Jennifer J.","family":"Schoch","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav N.","family":"Tolkachjov","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Cappel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence E.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester Minnesota"},{"name":"Division of Anatomic Pathology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn Marie R.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester 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