{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:15:25Z","timestamp":1771305325321,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>A combination of narrowband ultraviolet B (<jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content>) phototherapy plus topical tacrolimus has been used in adult vitiligo but has not yet been explored in children. We therefore sought to highlight the efficacy of this synergistic combination in childhood vitiligo. The objective was to study the clinical efficacy and safety of a combination of <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> with topical tacrolimus ointment 0.03% in childhood vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this open\u2010label study, 20 children, 4 to 14 years of age, with symmetrical vitiligo lesions were enrolled for 24 weeks. All were instructed to apply tacrolimus ointment 0.03% on a target patch on the left side of the body twice daily and no topical on a target patch on the right side. The whole body was irradiated with <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> three times per week. All patients were examined and the same dermatologist photographed lesions to assess for repigmentation at 4\u2010week intervals. Response was noted as the percentage of repigmentation (none, 0%; poor, 1\u201325%; moderate, 26\u201350%; good, 51\u201375%; excellent, &gt;75%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Our study found a statistically significant difference in the mean percentage of repigmentation at 4 and 6 months between combination therapy and <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> monotherapy. The mean cumulative dose and average number of exposures for the first clinically visible response were significantly lower with combination therapy. No serious adverse events were noted during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our preliminary data suggest that a combination of <jats:styled-content style=\"fixed-case\">NBUVB<\/jats:styled-content> phototherapy with topical tacrolimus is a highly effective and promising therapeutic option for vitiligo in children, whose treatment options are very limited, but long\u2010term studies are needed to evaluate the future risk of malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.12991","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T14:16:12Z","timestamp":1476281772000},"page":"646-651","source":"Crossref","is-referenced-by-count":21,"title":["Treatment of Childhood Vitiligo Using Tacrolimus Ointment with Narrowband Ultraviolet B Phototherapy"],"prefix":"10.1111","volume":"33","author":[{"given":"Surabhi","family":"Dayal","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereolgy and Leprology Pt. B. D. Sharma Post Graduate Institute of Medical Sciences Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyadarshini","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereolgy and Leprology Pt. B. D. Sharma Post Graduate Institute of Medical Sciences Rohtak Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Skin Clinic Kurukshetra Haryana India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.32708"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-014-0098-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05377.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01632.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12226"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90133-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01837.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.22319.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.036"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.113091"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.7.927"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02101.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb03978.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088505"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.10.022"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12111"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.050"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06280.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00600.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12991","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T18:21:25Z","timestamp":1695752485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,4]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/pde.12991"],"URL":"https:\/\/doi.org\/10.1111\/pde.12991","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,4]]}}}