{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:00:38Z","timestamp":1792036838580,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infantile hemangioma (IH) with minimal or arrested growth (IH\u2010MAG) is becoming increasingly recognized in the literature. It is important to be aware of their existence, because the correct diagnosis is essential for prognostication and treatment and, in the case of facial segmental lesions, the direction of further investigations if <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> (posterior fossa abnormalities and other structural brain abnormalities; hemangioma(s) of the cervical facial region; arterial cerebrovascular anomalies; cardiac defects, aortic coarctation, and other aortic abnormalities; eye anomalies) syndrome or Sturge\u2013Weber syndrome is suspected. Although the clinical and histologic characteristics of IH\u2010MAG resemble capillary malformations, positive <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 status is a delineating feature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed nine cases of infants who presented after 2000 with birthmarks showing unique clinical features suggestive of a special variant of IHs. All patients had serial photographs taken demonstrating resolution of the birthmark over time. Five of these cases had skin biopsy performed, all of which confirmed <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This photographic series of IH\u2010MAG demonstrates their unique clinical, histologic, and immunochemistry features. They were nearly fully formed at birth, and their common clinical features included telangiectasia, venules, and matte erythema with light and dark areas. Spontaneous resolution over time without cosmetic disfigurement was the observed natural history in the majority of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IH\u2010MAG is a unique clinical subset of hemangioma for which close observation is the preferred treatment. When in doubt, a biopsy for histology and <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 status may be needed to confirm the diagnosis before embarking on unnecessary laser treatment or medical interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.13022","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T09:52:41Z","timestamp":1479808361000},"page":"64-71","source":"Crossref","is-referenced-by-count":28,"title":["Infantile Hemangioma with Minimal or Arrested Growth: Further Observations on Clinical and Histopathologic Findings of this Unique but Underrecognized Entity"],"prefix":"10.1111","volume":"34","author":[{"given":"Ellen Hui","family":"Ma","sequence":"first","affiliation":[{"name":"Skin and Cancer Foundation Inc. Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Department of Dermatology Monash Health Melbourne Victoria Australia"},{"name":"Murdoch Childrens Research Institute Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung W.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Department of Pediatrics University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Bekhor","sequence":"additional","affiliation":[{"name":"Director of Laser Unit Royal Children's Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.197"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2006.00273.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.00102.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.200"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1567"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2767"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80192-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000197134.72984.cb"},{"key":"e_1_2_7_11_1","first-page":"559","article-title":"A unique microvascular phenotype shared by juvenile hemaniomas and human placenta","volume":"137","author":"North PE","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2007.1018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-009-9148-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.150284"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2007.1014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1684\/ejd.2010.0959","article-title":"Abortive hemangiomas. Description of clinical and pathological findings with special emphasis on dermoscopy","volume":"20","author":"Toledo\u2010Alberola F","year":"2010","journal-title":"Eur J Dermatol"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T15:18:40Z","timestamp":1695741520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,22]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/pde.13022"],"URL":"https:\/\/doi.org\/10.1111\/pde.13022","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,22]]}}}