{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:02:36Z","timestamp":1789642956073,"version":"4.0.0"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Costello syndrome (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) is a multisystem congenital disorder characterized by coarse facial features, cardiac defects, intellectual disability, and predisposition to malignancies. Dermatologic findings can include cutaneous papillomas, skin redundancy, acanthosis nigricans, and keratosis pilaris. Palmoplantar keratoderma (<jats:styled-content style=\"fixed-case\">PPK<\/jats:styled-content>) is present in approximately 76% of patients with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>, with disabling functional consequences in severe cases. We report a case of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> with severe <jats:styled-content style=\"fixed-case\">PPK<\/jats:styled-content> that improved dramatically with systemic administration of acitretin 0.3 mg\/kg\/day.<\/jats:p>","DOI":"10.1111\/pde.13057","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T21:11:19Z","timestamp":1482613879000},"page":"160-162","source":"Crossref","is-referenced-by-count":9,"title":["Palmoplantar Keratoderma in Costello Syndrome Responsive to Acitretin"],"prefix":"10.1111","volume":"34","author":[{"given":"Nareh V.","family":"Marukian","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Levinsohn","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany G.","family":"Craiglow","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Yale University New Haven Connecticut"},{"name":"Department of Pediatrics School of Medicine Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard M.","family":"Milstone","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Choate","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Yale University New Haven Connecticut"},{"name":"Department of Genetics School of Medicine Yale University New Haven Connecticut"},{"name":"Department of Pathology School of Medicine Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1641"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10744.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.4.439"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050420"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.003"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.13057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.13057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:30:31Z","timestamp":1696023031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.13057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,23]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/pde.13057"],"URL":"https:\/\/doi.org\/10.1111\/pde.13057","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,23]]}}}